Immunological and clinical differences between juvenile and adult onset of systemic lupus erythematosus
| Autor: | Margarita Rodríguez-Mahou, Luis Carreño, Francisco Javier López-Longo, M Bascones, Indalecio Monteagudo, C Saint-Cyr, Carlos M. González, Normand Lapointe |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Discoid lupus erythematosus Adolescent Extractable nuclear antigens Enzyme-Linked Immunosorbent Assay 030204 cardiovascular system & hematology Gastroenterology Nephropathy Cell Line 03 medical and health sciences 0302 clinical medicine Lupus Erythematosus Discoid Rheumatology Internal medicine medicine Animals Humans Lupus Erythematosus Systemic Age of Onset skin and connective tissue diseases Child Hematuria 030203 arthritis & rheumatology Lupus erythematosus business.industry Incidence (epidemiology) Age Factors Radioimmunoassay Complement C4 Complement C3 medicine.disease Immunoglobulin A Rats Immunoglobulin M Antibodies Antinuclear Child Preschool Immunoglobulin G Immunology Female Age of onset business Biomarkers Anti-SSA/Ro autoantibodies |
| Zdroj: | Lupus. 8(4) |
| ISSN: | 0961-2033 |
| Popis: | Introduction: Systemic lupus erythematosus (SLE) in children usually follows a more severe course than in adults, but sometimes in the previous studies reported there are many confounding factorsObjective: To analyse the immunological and clinical characteristics of SLE juvenile onset and SLE adult onset.Methods: We studied 179 patients with SLE, 49 patients were aged 6 – 18 yrs at onset of disease. Anti-dsDNA antibodies were detected by radioimmunoassay and antibodies to extractable nuclear antigens (ENA): anti-nRNP, anti-Sm, anti-Ro/SS-A and anti-La/SS-B antibodies by ELISA, counterimmuno-electrophoresis and immunoblotting.Results: Juvenile-onset SLE shows a higher frequency of cutaneous vasculitis (44.8% vs 27.6%; P < 0.05), seizures (18.3% vs 7.6%; P < 0.05) nephropathy (67.3% vs 48.4%; P < 0.025), and discoid lupus erythematosus (26.5% vs 13.8%; P < 0.05). The incidence of articular manifestations is lower than in adults (85.7% vs 96.1%; P < 0.025). No significant differences were found between the two groups in relation with the prevalence of antinuclear antibodies.Conclusions: Juvenile-onset SLE has more frequent neurological and renal manifestations than adult-onset SLE, but immunological markers are similar in both groups. These features suggest the most severe clinical manifestations in the juvenile-onset SLE group are not related with the presence of studied antibodies by different methods. |
| Databáze: | OpenAIRE |
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