Gene set enrichment analysis to create polygenic scores: a developmental examination of aggression
| Autor: | Kit K. Elam, Daniel S. Shaw, Melvin N. Wilson, Kathryn Lemery-Chalfant, Sierra Clifford |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Longitudinal sample Male Multifactorial Inheritance Poison control Polymorphism Single Nucleotide Article lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Risk Factors Injury prevention Human behaviour medicine Humans Genetic Predisposition to Disease Early childhood Set (psychology) Child Gene lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Aggression Genomics Psychiatry and Mental health 030104 developmental biology Phenotype Child Preschool Female medicine.symptom Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Translational Psychiatry, Vol 9, Iss 1, Pp 1-12 (2019) Translational Psychiatry |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-019-0513-7 |
| Popis: | Previous approaches for creating polygenic risk scores (PRSs) do not explicitly consider the biological or developmental relevance of the genetic variants selected for inclusion. We applied gene set enrichment analysis to meta-GWAS data to create developmentally targeted, functionally informed PRSs. Using two developmentally matched meta-GWAS discovery samples, separate PRSs were formed, then examined in time-varying effect models of aggression in a second, longitudinal sample of children (n = 515, 49% female) in early childhood (2–5 years old), and middle childhood (7.5–10.5 years old). Functional PRSs were associated with aggression in both the early and middle childhood models. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|