Cross-protective immunity in calves conferred by a DNA adenine methylase deficient Salmonella enterica serovar Typhimurium vaccine
| Autor: | Michael J. Mahan, Doug M. Heithoff, Keith Walker, Michael A. Hornitzky, Craig S. McConnell, V.L. Mohler, Lucy W.C. Shum, John K. House |
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| Rok vydání: | 2006 |
| Předmět: |
Diarrhea
Salmonella typhimurium Serotype Site-Specific DNA-Methyltransferase (Adenine-Specific) Salmonella Fever Salmonella Vaccines animal diseases Heterologous Cross immunity Biology medicine.disease_cause Microbiology Feces Species Specificity Immunity medicine Animals Salmonella Infections Animal General Veterinary General Immunology and Microbiology Public Health Environmental and Occupational Health biology.organism_classification Virology Vaccination B vitamins Infectious Diseases Salmonella enterica Molecular Medicine Cattle Lymph Nodes Gene Deletion |
| Zdroj: | Vaccine. 24:1339-1345 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2005.09.022 |
| Popis: | The global trend towards intensive livestock production is associated with increased fecal oral pathogen transmission resulting in a high prevalence of Salmonella . Since many pathogenic Salmonella serovars are often endemic to livestock production systems, it is desirable to develop a vaccine that is capable of eliciting immunity to more than one serovar. Here we examined whether immunization with a modified live Salmonella enterica serovar Typhimurium vaccine strain lacking the DNA adenine methylase (Dam) conferred protection in calves against a heterologous S. enterica Dublin challenge. Vaccinated animals challenged with a virulent Dublin strain exhibited a significant attenuation of clinical disease (improved attitude scores and reduced fever and diarrhea) and a concomitant reduction in Dublin fecal shedding and colonization of mesenteric lymph nodes (MLN) compared to non-vaccinated control animals. These data suggest that vaccination with a dam − Typhimurium vaccine strain conferred significant cross-protection against clinical disease in cattle attributable to heterologous challenge with Dublin. |
| Databáze: | OpenAIRE |
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