Stilbenoids from aerial parts of Dendrobium plicatile
| Autor: | Yu-Ye Wang, Yue-Juan Chen, Dan-Na Chen, Ya-Ping Wu, Wen-Jian Liu, Lin Jiang, Feng He, Jing-Xian Wang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Orchidaceae
Traditional medicine 010405 organic chemistry Organic Chemistry Plant Science Stilbenoid Biology biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Bibenzyl Dendrobium plicatile |
| Zdroj: | Natural Product Research. 34:323-328 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2018.1530996 |
| Popis: | Chemical investigation of Dendrobium plicatile Lindl resulted in the isolation and identification of one new bibenzyl, 2-chloro-3, 4’-dihydroxy-3’,5-dimethoxybibenzyl (1), as well as 15 known stilbenoids. The structures of this new compound was elucidated by extensive spectroscopic analysis, including HRESIMS, 1H and 13C NMR, DEPT, HMBC, COSY, HMQC, NOESY. Compounds 2, 3 and 5 were obtained from this genus for the first time, compounds 8, 10, 13 and 14 were obtained from this plant for the first time. In addition, the new compound exhibited potent cytotoxic activities against the human breast cancer (MDA-MB231) cell line, the hepatocellular carcinoma (HepG2) cell line and the human lung carcinoma (A549) cell line, with IC50 3.41, 3.02, 2.80 μM, respectively. |
| Databáze: | OpenAIRE |
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