Polyphenols of cambuci (Campomanesia phaea (O. Berg.)) fruit ameliorate insulin resistance and hepatic steatosis in obese mice
| Autor: | Larissa Rodrigues, Érique Castro, Márcio Hercules Caldas Moura, Maria Inés Genovese, William T. Festuccia, Priscila R. dos Santos-Donado, Carlos M. Donado-Pestana, Érika Vicência Monteiro Pessoa, Rafaela Rossi |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Myrtaceae Mice Obese Inflammation Campomanesia Diet High-Fat 01 natural sciences Analytical Chemistry RESISTÊNCIA À INSULINA Mice chemistry.chemical_compound 0404 agricultural biotechnology Insulin resistance Non-alcoholic Fatty Liver Disease Internal medicine parasitic diseases medicine Animals Obesity Gallic acid Protein kinase B biology business.industry 010401 analytical chemistry Polyphenols AMPK 04 agricultural and veterinary sciences General Medicine medicine.disease biology.organism_classification 040401 food science 0104 chemical sciences Mice Inbred C57BL Endocrinology chemistry Fruit Insulin Resistance medicine.symptom Steatosis business Food Science |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Polyphenols from cambuci (CBC) (Campomanesia phaea (O. Berg.)), a Brazilian native fruit, were investigated on therapeutic actions mitigating insulin resistance and hepatic steatosis in high-fat-sucrose diet (HFS) induced obese mice. For this, C57BL/6J mice fed with a obesogenic and diabetogenic HFS diet were administered with either water or two CBC doses (36 or 74 mg gallic acid equivalent (GAE)/kg body weight) by gavage from week 6 to week 14 (end-point) of HFS feeding. CBC reduced body weight gain, inflammation, hepatic steatosis, hyperglycemia, glucose intolerance, and insulin resistance in liver and skeletal muscle of obese mice, and such effects were associated with activation of Akt and AMPK in these tissues. In conclusion, polyphenols from CBC show important therapeutic actions ameliorating obesity-associated complications. |
| Databáze: | OpenAIRE |
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