Development of thermostable vaccine adjuvants
| Autor: | Christopher B. Fox, Yizhi Qi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Engineering Process development medicine.medical_treatment Immunology Article 03 medical and health sciences 0302 clinical medicine Vaccine adjuvant Adjuvants Immunologic Drug Discovery medicine Humans 030212 general & internal medicine Adjuvants Vaccine Pharmacology Vaccines business.industry Aluminum salts 030104 developmental biology Risk analysis (engineering) Expert opinion Molecular Medicine Narrative review business Adjuvant Expansive |
| Zdroj: | Expert Rev Vaccines |
| Popis: | INTRODUCTION: The importance of vaccine thermostability has been robustly discussed in the literature. Nevertheless, the challenge of developing thermostable vaccine adjuvants has sometimes not received appropriate emphasis. Adjuvants comprise an expansive range of particulate and molecular compositions, requiring innovative thermostable formulation and process development approaches. AREAS COVERED: Reports on efforts to develop thermostable adjuvant-containing vaccines have increased in recent years, and substantial progress has been made in enhancing stability of the major classes of adjuvants. This narrative review summarizes the current status of thermostable vaccine adjuvant development and looks forward to the next potential developments in the field. EXPERT OPINION: As adjuvant-containing vaccines become more widely used, the unique challenges associated with developing thermostable adjuvant formulations merit increased attention. In particular, more focused efforts are needed to translate promising proof-of-concept technologies and formulations into clinical products. |
| Databáze: | OpenAIRE |
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