Aldicarb Toxicosis in a Flock of Sheep
| Autor: | Gavin L. Meerdink, David C. Dorman, Wanda M. Haschek, Karen A. Harlin, Steven S. Ross, Carl A. Wisse |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
0301 basic medicine
Hypersalivation Miosis Pathology medicine.medical_specialty Carbamate Rumen Aldicarb 040301 veterinary sciences medicine.medical_treatment 030106 microbiology Sheep Diseases Physiology Pulmonary Edema Retina 0403 veterinary science Death Sudden 03 medical and health sciences chemistry.chemical_compound medicine Animals Whole blood Cholinesterase Sheep General Veterinary biology business.industry Poisoning Carbamate poisoning Brain 04 agricultural and veterinary sciences Pulmonary edema medicine.disease Gastrointestinal Contents chemistry Acetylcholinesterase biology.protein Female medicine.symptom business |
| Zdroj: | Journal of Veterinary Diagnostic Investigation. 4:45-47 |
| ISSN: | 1943-4936 1040-6387 |
| DOI: | 10.1177/104063879200400110 |
| Popis: | Aldicarb toxicosis was diagnosed in 200 sheep that died suddenly. Carbamate insecticide toxicosis was suspected based on observed clinical signs (hypersalivation, diarrhea, urination, paddling, seizures, miosis, and deaths occurring within 1 hour). Tissue samples were submitted from 4 Columbian ewes for pathologic and analytical evaluation. Severe diffuse pulmonary edema was observed on gross and histologic examination. Inhibition of cholinesterase activity in retina (21.2–68.1% of normal activity, n = 3), brain (40.6–45.6% of normal activity, n = 3), and whole blood (27% of normal activity, n = 1) supported a diagnosis of carbamate toxicosis. Reversal of brain and whole blood cholinesterase activities (reactivation factor > 1.4) following an in vitro 1 hour incubation at 37 C was also consistent with carbamate poisoning. Aldicarb toxicosis was confirmed following its detection in rumen contents at 1.5, 5.5, and 334 ppm using both high-pressure liquid chromatography with UV detection and gas chromatography with nitrogen/phosphorus detection. |
| Databáze: | OpenAIRE |
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