Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia
| Autor: | M Martineau, Kan Luk Cheung, Brenda Gibson, Christine J. Harrison, Tim O B Eden, Sally E. Kinsey, Zoë J. Broadfield, Rachel L. Harris, G. Reza Jalali, Kerry E. Taylor, Hazel M. Robinson, Ian Hann, Frank Hill, Chris Mitchell, Anthony V. Moorman, Sue Richards |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Multivariate analysis Adolescent Immunology Aneuploidy Trisomy Biochemistry Disease-Free Survival Sex Factors Acute lymphocytic leukemia Internal medicine Humans Medicine Child In Situ Hybridization Fluorescence Proportional Hazards Models Univariate analysis business.industry Proportional hazards model Age Factors Infant Cell Biology Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis medicine.disease Diploidy Treatment Outcome El Niño Child Preschool Karyotyping Multivariate Analysis Female Hyperdiploidy business |
| Zdroj: | Blood. 102:2756-2762 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | High hyperdiploidy (HeH) (51 to 65 chromosomes) is found in one third of children with acute lymphoblastic leukemia and is associated with a good prognosis. Cytogenetic features may further refine this prognosis and identify patients with a poor outcome. We examined the effect of sex, age, individual trisomies, modal number, and structural abnormalities on survival among 700 children with HeH. Univariate analysis showed that age. sex, +4, +10, +18, and a high modal number were associated with survival. Multivariate analysis however, revealed that only age, sex, +4, and +18 were independent indicators. Hazard scores for predicting relapse and mortality were constructed. Three risk groups with 5-year event-free survival (EFS) rates of 86%, 75%, and 50% (P |
| Databáze: | OpenAIRE |
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