Remote Ischemic Post-Conditioning may Improve Post-Stroke Cognitive Impairment: A Pilot Single Center Randomized Controlled Trial
| Autor: | Yue-juan li, Long Zhang, Ya-mei Hu, Keke Liang, Rui Pan, Jianhua Zhao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
China medicine.medical_specialty Time Factors Post conditioning Pilot Projects Single Center law.invention 03 medical and health sciences Cognition 0302 clinical medicine Randomized controlled trial law medicine Humans Cognitive Dysfunction Ischemic Postconditioning Cognitive impairment Aged Aged 80 and over business.industry Rehabilitation Montreal Cognitive Assessment Recovery of Function Middle Aged Stroke Clinical trial Treatment Outcome Tolerability Physical therapy Feasibility Studies Female Surgery Neurology (clinical) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Stroke and Cerebrovascular Diseases. 29:105217 |
| ISSN: | 1052-3057 |
| Popis: | We aimed to demonstrate the tolerability and feasibility and the effect of remote ischemic post-conditioning on cognitive functioning in patients with post-stroke cognitive impairment.This was a single-center, randomized, outcome-blinded, placebo-controlled trial, randomized 1:1 to receive 4 cycles of remote ischemic post-conditioning or a sham procedure for 7 days. The primary outcome measure was tolerability and feasibility of remote ischemic post-conditioning. Secondary outcomes to measure the neurological function with national institute of health stroke scale and the cognitive impairment with Montreal Cognitive Assessment scale and Alzheimer's disease assessment scale-cognitive (at baseline, 90 days, 180 days).48 patients (24 RIPC and 24 Control) were recruited. remote ischemic post-conditioning was well tolerated with 90 out of 96 cycles completed in full. 4 patients experienced vascular events in the control group: 3 cerebrovascular and 1 cardiovascular event versus only 2 cerebrovascular events in the RIPC group. We showed the similar result in the neurological function with national institute of health stroke scale score with no statistically significant differences between RIPC and control group at baseline (P = 0.796) and 90 days (P = 0.401) and 180 days (P = 0.695). But compare with baseline, it was significantly difference in the control and RIPC group at 90 days (P 0.05) and 180 days (P 0.05). The comparison of Montreal Cognitive Assessment scale between two groups both showed that P 0.05 at baseline which was no statistical difference, but P 0.05 at 90 days and 180 days which were significant statistical difference. The comparison of Alzheimer's disease assessment scale-cognitive between two groups showed that P 0.05 at baseline (P = 0.955) and 90 days (P = 0.138) was no statistical difference, but P = 0.0050.05 at 180 days was significant statistical difference.The remote ischemic post-conditioning for post-stroke cognitive impairment was well tolerated, safe and feasible. The remote ischemic post-conditioning may improve neurological and cognitive outcomes in patients with post-stroke cognitive impairment. A larger trial is warranted. (Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: ChiCTR1800015231.). |
| Databáze: | OpenAIRE |
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