Fixed-Combination Halobetasol Propionate and Tazarotene in the Treatment of Psoriasis: Narrative Review of Mechanisms of Action and Therapeutic Benefits
| Autor: | Linda Stein Gold, Abby Jacobson, James Q Del Rosso, Nelly K Gilyadov, Mark Lebwohl, Emil Tanghetti |
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| Rok vydání: | 2021 |
| Předmět: |
Efficacy
Halobetasol propionate Review Dermatology Tazarotene Pharmacology Duobrii 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Psoriasis Corticosteroid Medicine Lotion Active ingredient Halobetasol Propionate business.industry Therapeutic effect medicine.disease Clinical trial Formulation Tolerability 030220 oncology & carcinogenesis Retinoid Safety business medicine.drug |
| Zdroj: | Dermatology and Therapy |
| ISSN: | 2190-9172 2193-8210 |
| DOI: | 10.1007/s13555-021-00560-6 |
| Popis: | Psoriasis is a lifelong disease associated with cycles of remission and relapse. Topical treatments are the front line of psoriasis therapy for most patients and have antiproliferative, anti-inflammatory, and immunosuppressive mechanisms of action. Novel fixed-dose combinations of topical therapeutic agents are becoming increasingly available, leveraging multiple mechanisms of action to improve safety and efficacy with formulations that are easier to use and may allow for the use of lower doses of active ingredients. A fixed-combination lotion containing the potent-to-superpotent corticosteroid halobetasol propionate (HP) and the retinoid tazarotene (HP 0.01%/TAZ 0.045%) was recently developed using polymeric emulsion technology. This new formulation technology allows for more uniform and efficient delivery of the active ingredients at lower doses than conventional monotherapy formulations of either ingredient while providing enhanced hydration and moisturization. This review provides an up-to-date overview of the therapeutic mechanisms of action of HP and TAZ, the rationale behind the development of HP 0.01%/TAZ 0.045% lotion, and clinical trials data on the efficacy, safety and tolerability, and maintenance of therapeutic effect with HP 0.01%/TAZ 0.045% lotion in the treatment of moderate-to-severe plaque psoriasis. |
| Databáze: | OpenAIRE |
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