SNP-SNP interactions in the BDNF, COMT, CBR1 and CCK genes, associated with post-traumatic stress disorder in urban residents of Itagüí, Colombia
| Autor: | Pablo Andrés Guzmán-González, Juliana Martínez-Garro, Mariana Duque-Quintero, Yolanda Torres de Galvis, Gloria María Sierra-Hincapié |
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| Rok vydání: | 2020 |
| Předmět: |
Risk Ratio (MeSH)
Extinción psicológica Polimorfismo de nucleótido simple Single-nucleotide polymorphism Lower risk Logistic regression Polymorphism Single Nucleotide Extinction Psychological Stress Disorders Post-Traumatic 03 medical and health sciences 0302 clinical medicine Factores de riesgo (DeCS) Genotype Medicine SNP 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Allele Genetics business.industry 05 social sciences Traumatic stress General Medicine medicine.disease Trastornos por estrés postraumático business 030217 neurology & neurosurgery Psychological trauma |
| Zdroj: | Revista de la Facultad de Medicina, Volume: 68, Issue: 4, Pages: 550-555, Published: 16 JAN 2021 |
| ISSN: | 2357-3848 0120-0011 |
| Popis: | Introduction: Single nucleotide polymorphisms (SNPs) in the BDNF, COMT, CBR1 and CCK genes have been associated with the process of fear extinction in humans. Since fear extinction plays a key role in recovering from psychological trauma, there is a possibility that these genes modulate the risk of developing post-traumatic stress disorder (PTSD). Objective: To assess unilocus and multilocus associations between SNPs in the BDNF, COMT, CBR1 and CCK genes and the risk of developing PTSD. Materials and methods: 129 inhabitants of the municipality of Itagüí, Colombia, who had experienced psychological trauma at least once, were genotyped for these polymorphisms (38 cases of PTSD and 91 controls). Logistic regression was used to perform unilocus and multilocus association tests for single SNPs and existing SNP-SNP genotypic combinations. Results: No unilocus associations were found, but interactions between the BDNF and CBR1 genes and between the COMT and CCK genes were observed. Of these interactions, the genotypic combinations that behaved as risk factors were AG-AA (OR=13.52, p |
| Databáze: | OpenAIRE |
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