Molecular biology of 5-HT receptors
| Autor: | F.G. Boess, I.L. Martin |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pharmacology
Agonist 7-OH-DPAT medicine.drug_class Chemistry Molecular Sequence Data Class C GPCR Cellular and Molecular Neuroscience chemistry.chemical_compound Biochemistry Receptors Serotonin medicine Animals Humans Amino Acid Sequence Serotonin Signal transduction Receptor Endogenous agonist 5-HT receptor |
| Zdroj: | Neuropharmacology. 33:275-317 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/0028-3908(94)90059-0 |
| Popis: | The receptors through which serotonin (5-hydroxytryptamine, 5-HT) produces its effects have been the subject of intense investigation, initially using both in vivo and in vitro pharmacological methods, and later radioligand binding. These approaches allowed a preliminary classification of 5-HT receptors, but the identification on subtypes was limited by the selectivity on the available agonists and antagonists. Bradley et al. (1986) distinguished three main classes of 5-HT receptors: 5-HT 1 , 5-HT 2 and 5-HT 3 . 5-HT 3 receptors were activated by the selective agonist 2-methyl-5-HT and blocked by selective antagonists such as (-)cocaine, MDL72222 and tropisetron (ICS 205-930) |
| Databáze: | OpenAIRE |
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