Targeting FGFRs for tumor therapy: current status and novel strategies
| Autor: | Yunzhou Dong, Changyu Ren, Mengli Zhu, Dan Zhang, Ting Wang, Jifa Zhang, Jiaxing Wang, Wuyu Mao, Fangyi Long |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Future Medicinal Chemistry. 14:1923-1941 |
| ISSN: | 1756-8927 1756-8919 |
| Popis: | The FGF receptors (FGFRs) belong to a family of receptor tyrosine kinases. Abundant evidence shows that FGFRs are closely related to tumor cell invasion and angiogenesis. Hence, targeted modulation of FGFRs has become an effective strategy for cancer treatment. Recently, the development of small-molecule inhibitors targeting FGFRs has been extensively studied, and three inhibitors have been approved for marketing. Based on the clinical problems with the current inhibitors, there is a need to develop novel inhibitors and technologies to address the pitfalls. This review summarizes recent advances in small-molecule inhibitors targeting FGFRs, focusing on structure–activity relationships. Moreover, recent progress of novel technologies are summarized to provide a reference for promoting the application of drugs targeting FGFRs in tumor therapy. |
| Databáze: | OpenAIRE |
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