Plasma triglycerides and lipoprotein(a): inverse relationship in a hyperlipidemic Italian population
| Autor: | Gemma Gianfranceschi, Silvia Michelagnoli, Cesare R. Sirtori, JoséP. Werba, Guido Franceschini, O. Safa |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Population Hypercholesterolemia Hyperlipidemias Hyperlipoproteinemia Type V chemistry.chemical_compound Internal medicine Blood plasma medicine Humans education Triglycerides Aged Aged 80 and over Hypertriglyceridemia education.field_of_study biology Triglyceride business.industry Cholesterol Cholesterol HDL Lipoprotein(a) Cholesterol LDL Middle Aged medicine.disease Italian population Endocrinology chemistry Italy biology.protein lipids (amino acids peptides and proteins) Female Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Atherosclerosis. 101(2) |
| ISSN: | 0021-9150 |
| Popis: | The relationship between plasma lipoprotein(a) (Lp(a)) levels and other clinical/biochemical variables was investigated in 1200 consecutive hyperlipidemic patients. Plasma Lp(a) concentrations were measured by a sandwich-ELISA method, while the patients were either on diet or diet plus lipid-lowering drugs; 38% of them had a plasma Lp(a) level > 30 mg/dl. The median plasma Lp(a) concentration and the frequency of Lp(a) > 30 mg/dl were significantly lower in individuals with severe hypertriglyceridemia vs. hypercholesterolemics (HC) or mixed hyperlipidemics (M-HLP), but similar to normolipidemic healthy controls. Patients with isolated moderate hypertriglyceridemia had Lp(a) levels intermediate between HC and M-HLP subjects. The in vitro addition of triglyceride-rich lipoproteins to normotriglyceridemic plasma did not affect the Lp(a) measurement. Plasma Lp(a) concentrations in the whole hyperlipidemic population correlated negatively with triglycerides and positively with total cholesterol, HDL-cholesterol and age, being unrelated to either body mass index or lipid-lowering treatment. In HC patients, the presence of tendon xanthomas was associated with twofold higher Lp(a) levels. These findings argue for a regulatory role of triglycerides on plasma Lp(a) levels in hyperlipidemic patients. |
| Databáze: | OpenAIRE |
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