Aspergillus species: An emerging pathogen in onychomycosis among diabetics
| Autor: | T.D.C.P. Gunasekara, T.M. Wijesuriya, M.M. Weerasekara, U. Bulugahapitiya, S S Neluka Fernando, K. N. P. Ranasinghe, J Kottahachchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Nail Infection Endocrinology Diabetes and Metabolism lcsh:Diseases of the endocrine glands. Clinical endocrinology Microbiology Emerging pathogen Endocrinology Internal medicine Diabetes mellitus onychomycosis Medicine lcsh:RC799-869 skin and connective tissue diseases Aspergillus species Pathogen Sri Lanka Aspergillus lcsh:RC648-665 integumentary system biology business.industry Aspergillus niger biology.organism_classification medicine.disease Original Article lcsh:Diseases of the digestive system. Gastroenterology Sri lanka business diabetics |
| Zdroj: | Indian Journal of Endocrinology and Metabolism, Vol 19, Iss 6, Pp 811-816 (2015) Indian Journal of Endocrinology and Metabolism |
| ISSN: | 2230-9500 2230-8210 |
| Popis: | Introduction: Approximately, 33% patients with diabetes are afflicted with onychomycosis. In the past, nondermatophyte molds have been regarded as opportunistic pathogens; recently, Aspergillus species are considered as emerging pathogens of toenail infections. In Sri Lanka, the prevalence of Aspergillus species in onychomycosis among diabetics is not well documented. Objective: To determine the proportion of Aspergillus onychomycosis, risk factors and knowledge among diabetics. Materials and Methods: This was descriptive cross-sectional study. Three hundred diabetic patients were included. Clinical examinations of patients’ toenails were performed by a clinical microbiologist. Laboratory identification was done, and pathogens were identified to the species level by morpho-physiological methods. All inferential statistics were tested at P < 0.05. Results: Among clinically suspected patients, 85% (255/300) were mycologically confirmed to have onychomycosis. Aspergillus species were most commonly isolated n = 180 (71%) followed by dermatophytes, yeasts, and other molds n = 75 (29%). Of the patients having Aspergillus onychomycosis, 149 (83%) were in the > age group. In men, Aspergillus onycomycosis was seen in 82%. Among patients who had Aspergillus nail infection, 114 (63%) had diabetes for a period of > years. Among patients who were engaged in agricultural activities, 77% were confirmed to have infected nails due to Aspergillus species. Conclusion: Aspergillus niger was the most common pathogen isolated from toenail infection. Aspergillus species should be considered as an important pathogen in toenail onychomycosis in diabetic patients. Risk factors associated with Aspergillus onychomycosis were age, gender, duration of diabetes, length of exposure to fungi, and occupation. |
| Databáze: | OpenAIRE |
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