Effect of Corynebacterium parvum on peripheral blood platelets
| Autor: | J. E. Castro, Sadler Te, Jones Pd |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pathology Lung Neoplasms Time Factors Metastasis Mice Propionibacterium acnes Internal medicine medicine Animals Platelet Neoplasm Metastasis Strain (chemistry) biology Heparin business.industry Lewis lung carcinoma Neoplasms Experimental medicine.disease biology.organism_classification Thrombocytopenia Peripheral blood Bacterial vaccine Endocrinology Oncology Bacterial Vaccines Female business Research Article medicine.drug |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1977.261 |
| Popis: | The level of peripheral blood platelets was determined after i.v. injection of Corynebacterium parvum in normal C57BL mice and in those bearing the Lewis lung carcinoma. Twenty minutes after injection of a formalin-killed active strain (CN6134, (CN6134, which inhibited tumour metastases) or a killed inactive strain (CN 5888, which did not inhibit metastases) the number of circulating blood platelets was reduced by 50%. The level of platelets returned to control values by 8 h after the active, and by approximately 3 days after the inactive strain. The active strain alone caused a second and prolonged fall in platelet numbers, from approximately 16 h to 21 days after injection. Heparin given 3 X weekly to these mice restored the platelet count to normal values by 10 days after injection of active-strain C. parvum. The level of platelets in tumour-bearing mice was essentially similar to that in normal mice. Possible causes of the thrombocytopenia and the significance of platelets in metastasis are discussed. |
| Databáze: | OpenAIRE |
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