Androgen receptor content in cytosol from non-tumoral human kidney and its relation to steroid hormone environment
| Autor: | S. de Castro, Larraitz Garcia, J M Miralles, J. J. Corrales, Justo Gonzalez, José Antonio Alcázar Montero, Isabel Pastor |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Colon Urology medicine.medical_treatment In Vitro Techniques Kidney Perineum chemistry.chemical_compound Radioligand Assay Dehydroepiandrosterone sulfate Cytosol Internal medicine Testis medicine Humans Androstenedione Estrenes Receptor Testosterone Congeners Testosterone Aged business.industry Prostate Estrogens Metribolone Middle Aged Androgen Androgen receptor Steroid hormone Endocrinology chemistry Receptors Androgen Androgens Female business Hormone |
| Zdroj: | Urologia internationalis. 40(6) |
| ISSN: | 0042-1138 |
| Popis: | The content of cytoplasmic androgen receptors (Bmax) was analyzed in non-tumoral renal tissue of 12 men and 15 postmenopausal women using a synthetic androgen (methyltrienolone) as ligand and a method of dextran-coated charcoal. The Bmax in both sexes was compared, establishing correlations between it and circulating levels of testosterone, dehydroepiandrosterone sulfate, androstenedione, and estradiol to find out the possible influence of the hormonal environment on androgen receptors in the human kidney. No differences in Bmax were observed between males (46.3 +/- 24 fmol/g of tissue) and females (45.4 +/- 26 fmol/g), in spite of the significantly greater (p less than 0.01) levels of circulating testosterone in the former group. No significant linear correlations existed between any of the steroids analyzed and the Bmax. These results demonstrate the existence of androgenic receptors in non-tumoral human kidney and indicate that its content is not regulated by circulating levels of testosterone. The concentrations of the principal extratesticular androgens and estradiol do not seem to have a quantitative influence on these androphilic proteins either. |
| Databáze: | OpenAIRE |
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