Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?
| Autor: | M V Melnikov, Mikhail Pashenkov, Alexey Boyko |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Opinion
Encephalomyelitis Autoimmune Experimental Multiple Sclerosis QH301-705.5 Neuroimmunomodulation Dopamine Central nervous system Dopamine Agents Models Neurological Catalysis Receptors Dopamine neuroinflammation Inorganic Chemistry chemistry.chemical_compound Mice medicine Animals Humans Physical and Theoretical Chemistry Biology (General) Neurotransmitter Molecular Biology QD1-999 Spectroscopy Neuroinflammation business.industry Multiple sclerosis Organic Chemistry Dopaminergic Experimental autoimmune encephalomyelitis Models Immunological psychoneuroimmunology General Medicine medicine.disease Computer Science Applications Chemistry medicine.anatomical_structure chemistry Th17 Cells business Neuroscience medicine.drug Psychoneuroimmunology |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 5313, p 5313 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Dopamine is a neurotransmitter that mediates neuropsychological functions of the central nervous system (CNS). Recent studies have shown the modulatory effect of dopamine on the cells of innate and adaptive immune systems, including Th17 cells, which play a critical role in inflammatory diseases of the CNS. This article reviews the literature data on the role of dopamine in the regulation of neuroinflammation in multiple sclerosis (MS). The influence of dopaminergic receptor targeting on experimental autoimmune encephalomyelitis (EAE) and MS pathogenesis, as well as the therapeutic potential of dopaminergic drugs as add-on pathogenetic therapy of MS, is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|