Antibacterial prescription in Italian preschool children: analysis of 7 years of data from the Emilia-Romagna region reimbursement database
| Autor: | Domenico Motola, Giulia Bonaldo, Monia Donati, Lars Småbrekke, Alberto Vaccheri, Ottavio D'Annibali |
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| Přispěvatelé: | D'Annibali O., Bonaldo G., Donati M., Smabrekke L., Motola D., Vaccheri A. |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Male Pediatrics medicine.medical_specialty 030106 microbiology Drug Prescriptions 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sex Factors Prescription database Medicine Humans Pharmacology (medical) 030212 general & internal medicine Medical prescription Extended-spectrum penicillin Reimbursement Pharmacology Preschool child business.industry Reimbursement Mechanism Age Factors Infant Newborn Infant Drug Utilization Anti-Bacterial Agents Infectious Diseases chemistry Italy Child Preschool Costs and Cost Analysis Female business Antibacterial prescription Preschool children Emilia-romagna region Pharmacoepidemiology |
| Zdroj: | The Journal of antimicrobial chemotherapy. 74(8) |
| ISSN: | 1460-2091 |
| Popis: | Objectives To describe antibacterial prescribing patterns in outpatients aged 0–5 years from 2007 to 2013 in the Emilia-Romagna region, assessing sex- and age-specific consumption over time. Methods All children aged 0–5 years resident in the Emilia-Romagna region who received at least one prescription of a systemic antibacterial in the period 2007–13 were enrolled. The prescriptions of systemic antibacterials to children were collected from the regional prescription database. Data were stratified by year, sex and age, and analysed in terms of periodic prevalence and of annual prescription rate per 1000 person-years. Results The prevalence of children receiving at least one prescription per year varied from 68.0% in 2007 to 59.0% in 2013, while the average prevalence of children receiving five or more prescriptions per year was 6.96%. The annual prescription rate varied from 1621.26 in 2007 to 1372.27 in 2013. Penicillins + β-lactamase inhibitors accounted for 35.3% of total prescriptions, followed by extended-spectrum penicillins (28.6%), macrolides (17.0%) and third-generation cephalosporins (13.9%). Conclusions Despite recommendations, a significant overprescription of antibacterials to children still exists, showing no satisfactory improvements over the years. In contrast to Northern European countries, adherence to evidence-based guidelines was poor, with frequent prescribing of broad-spectrum agents for the treatment of mostly viral childhood infectious disease. |
| Databáze: | OpenAIRE |
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