Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model
| Autor: | Yuuki Shirai, Ken-ichi Mukaisho, Takahisa Nakayama, Yoshisato Machida, Shinya Koshinuma, Ryoji Kushima, Gaku Yamamoto, Masaki Mikami, Yasuyuki Asada |
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| Rok vydání: | 2022 |
| Předmět: |
Pathology
medicine.medical_specialty Oral surgery General Biochemistry Genetics and Molecular Biology Bone remodeling Dermis Animals Medicine Secondary healing Wound Healing Gelatin sponge integumentary system General Veterinary business.industry General Medicine Bandages Rats medicine.anatomical_structure Wound dressing Gelatin Cattle Animal Science and Zoology Collagen business Wound healing Bone surface |
| Zdroj: | Experimental Animals. 71:161-172 |
| ISSN: | 1881-7122 1341-1357 |
| Popis: | In oral surgery, tissue loss may occur in some cases, resulting in bone exposure and subsequent wound infection and possible scar formation during secondary healing. In this study, Terudermis® Artificial Dermis (AD-T), a dermal defect graft made from processed bovine dermis collagen and gelatin sponge (GS) were used as dressings on 100-mm2 wounds with exposed bone on the heads of rats. For the control group, the wound was left exposed. The wound-healing efficacy of the treatment was compared macroscopically and histologically among the three groups at 1, 2, and 4 weeks after surgery. Complete wound healing was achieved faster in the AD-T group than in the GS group, and osteoblasts appeared on the bone surface, indicating accelerated bone remodeling. Furthermore, in the AD-T group, there was an increased production of newly formed blood vessels, fibroblasts and osteoblasts positive for anti-cortactin antibodies, which are believed to contribute to wound healing. Our findings suggest that AD-T is better than GS as a wound dressing material. |
| Databáze: | OpenAIRE |
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