Gestational trophoblastic tumours following initial diagnosis of partial hydatidiform mole
| Autor: | K. D. BAGSHAWE, S. D. LAWLER, F. J. PARADINAS, J. DENT, P. BROWN, G. M. BOXER |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors medicine.medical_treatment Trophoblastic Neoplasms Chorionic Gonadotropin Gestational trophoblastic tumour Diagnosis Differential Chorioepithelioma Molar pregnancy Pregnancy Risk Factors medicine Humans Registries reproductive and urinary physiology Partial Hydatidiform Mole Retrospective Studies Gynecology Chemotherapy Retrospective review Ploidies business.industry Obstetrics Hydatidiform Mole Invasive Choriocarcinoma Obstetrics and Gynecology Retrospective cohort study General Medicine DNA Neoplasm Hydatidiform Mole Middle Aged medicine.disease Flow Cytometry female genital diseases and pregnancy complications embryonic structures Uterine Neoplasms Gestation Female Pregnancy Multiple business Pregnancy Complications Neoplastic Follow-Up Studies |
| Zdroj: | Lancet (London, England). 335(8697) |
| ISSN: | 0140-6736 |
| Popis: | 11 patients registered with an initial diagnosis of partial hydatidiform mole (PHM) subsequently required chemotherapy for a gestational trophoblastic tumour. In a retrospective review by histopathological examination and measurement of DNA ploidy, the diagnosis was confirmed as PHM in 5 cases and revised to complete hydatidiform mole in 4; in 2 cases there was no evidence of a molar pregnancy. 4 of the patients with PHM had no other known pregnancy before the gestational trophoblastic tumour and in 2 of these patients the tumour was diagnosed histologically as choriocarcinoma. Not all patients in whom PHM was diagnosed at referring hospitals proved to have the condition. Although the risk of a patient with PHM requiring chemotherapy for gestational trophoblastic tumour is of the order of 1 in 200, compared with 1 in 12 after a complete mole, there is no justification for excluding a patient from follow-up after the evacuation of a PHM. |
| Databáze: | OpenAIRE |
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