The effects of post-operative oxygen supply on blood oxygenation and acid-base status in rats anaesthetized with fentanyl/fluanisone and midazolam
Autor: | Stefanie Hansborg Kolstrup, Leander Gaarde, Peter Bollen |
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Rok vydání: | 2021 |
Předmět: |
Male
Pulmonology Physiology Fluanisone Anesthesiology Heart Rate Medicine and Health Sciences Anesthesia Respiratory function Acidosis Oxygen saturation (medicine) Multidisciplinary Pharmaceutics Respiration Butyrophenones Body Fluids Fentanyl Chemistry Blood Physical Sciences Breathing Medicine Arterial blood Anatomy medicine.symptom Research Article Chemical Elements medicine.drug Midazolam Science Cardiology Surgical and Invasive Medical Procedures Signs and Symptoms Drug Therapy Medical Hypoxia medicine Animals business.industry Biology and Life Sciences Hypoxia (medical) medicine.disease Rats Oxygen Respiratory acidosis Clinical Medicine Physiological Processes business |
Zdroj: | PLoS ONE, Vol 16, Iss 8, p e0255829 (2021) Gaarde, L, Kolstrup, S & Bollen, P 2021, ' The effects of post-operative oxygen supply on blood oxygenation and acid-base status in rats anaesthetized with fentanyl/fluanisone and midazolam ', PLOS ONE, vol. 16, no. 8, e0255829 . https://doi.org/10.1371/journal.pone.0255829 PLoS ONE PLoS ONE, Vol 16, Iss 8 (2021) |
ISSN: | 1932-6203 |
Popis: | In anaesthetic practice the risk of hypoxia and arterial blood gas disturbances is evident, as most anaesthetic regimens depress the respiratory function. Hypoxia may be extended during recovery, and for this reason we wished to investigate if oxygen supply during a one hour post-operative period reduced the development of hypoxia and respiratory acidosis in rats anaesthetized with fentanyl/fluanisone and midazolam. Twelve Sprague Dawley rats underwent surgery and were divided in two groups, breathing either 100% oxygen or atmospheric air during a post-operative period. The peripheral blood oxygen saturation and arterial acid-base status were analyzed for differences between the two groups. We found that oxygen supply after surgery prevented hypoxia but did not result in a significant difference in the blood acid-base status. All rats developed respiratory acidosis, which could not be reversed by supplemental oxygen supply. We concluded that oxygen supply improved oxygen saturation and avoided hypoxia but did not have an influence on the acid-base status. |
Databáze: | OpenAIRE |
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