Genome-wide association of anthropometric traits in African- and African-derived populations
Autor: | Helen N. Lyon, Rachel Hackett, Xiaofeng Zhu, Ilze Berzins, Johannah L. Butler, Bamidele O. Tayo, Kristin G. Ardlie, Joel N. Hirschhorn, Charleston W. K. Chiang, Richard S. Cooper, Colin A. McKenzie, Rainford J. Wilks, Amy Luke, Candace Guiducci, Guillaume Lettre, Thutrang T. Nguyen, Cameron D. Palmer, Adebowale Adeyemo, Terrence Forrester, Sun J. Kang, Daniel Shriner, Charles N. Rotimi, Tao Feng |
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Rok vydání: | 2010 |
Předmět: |
Adult
Jamaica Adolescent DNA Copy Number Variations Genotype Black People Nigeria Single-nucleotide polymorphism Genome-wide association study Biology Polymorphism Single Nucleotide Young Adult Genetics Humans Copy-number variation Molecular Biology Genetics (clinical) Aged Models Statistical Anthropometry Association Studies Articles General Medicine Middle Aged Black or African American Sample size determination Illinois Body mass index Imputation (genetics) Genome-Wide Association Study |
Zdroj: | Human Molecular Genetics. 19:2725-2738 |
ISSN: | 1460-2083 0964-6906 |
Popis: | Genome-wide association (GWA) studies have identified common variants that are associated with a variety of traits and diseases, but most studies have been performed in European-derived populations. Here, we describe the first genome-wide analyses of imputed genotype and copy number variants (CNVs) for anthropometric measures in African-derived populations: 1188 Nigerians from Igbo-Ora and Ibadan, Nigeria, and 743 African-Americans from Maywood, IL. To improve the reach of our study, we used imputation to estimate genotypes at approximately 2.1 million single-nucleotide polymorphisms (SNPs) and also tested CNVs for association. No SNPs or common CNVs reached a genome-wide significance level for association with height or body mass index (BMI), and the best signals from a meta-analysis of the two cohorts did not replicate in approximately 3700 African-Americans and Jamaicans. However, several loci previously confirmed in European populations showed evidence of replication in our GWA panel of African-derived populations, including variants near IHH and DLEU7 for height and MC4R for BMI. Analysis of global burden of rare CNVs suggested that lean individuals possess greater total burden of CNVs, but this finding was not supported in an independent European population. Our results suggest that there are not multiple loci with strong effects on anthropometric traits in African-derived populations and that sample sizes comparable to those needed in European GWA studies will be required to identify replicable associations. Meta-analysis of this data set with additional studies in African-ancestry populations will be helpful to improve power to detect novel associations. |
Databáze: | OpenAIRE |
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