North American ginseng (Panax quinquefolius) suppresses β-adrenergic-dependent signalling, hypertrophy, and cardiac dysfunction
| Autor: | Xilan Tang, Jenny Xue, Xiaohong Tracey Gan, Cathy Huang, Morris Karmazyn, Venkatesh Rajapurohitam, Edmund M.K. Lui |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Agonist medicine.medical_specialty Physiology medicine.drug_class Panax Adrenergic Cardiomegaly 030204 cardiovascular system & hematology Plant Roots Muscle hypertrophy Rats Sprague-Dawley Ventricular Dysfunction Left 03 medical and health sciences Ginseng 0302 clinical medicine Downregulation and upregulation Physiology (medical) Internal medicine medicine Animals Myocyte American ginseng Pharmacology Dose-Response Relationship Drug biology Plant Extracts business.industry Isoproterenol food and beverages General Medicine Adrenergic beta-Agonists Saponins biology.organism_classification medicine.disease Rats Endocrinology 030220 oncology & carcinogenesis Heart failure business Signal Transduction |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 94:1325-1335 |
| ISSN: | 1205-7541 0008-4212 |
| Popis: | There is increasing evidence for a beneficial effect of ginseng on cardiac pathology. Here, we determined whether North American ginseng can modulate the deleterious effects of the β-adrenoceptor agonist isoproterenol on cardiac hypertrophy and function using in vitro and in vivo approaches. Isoproterenol was administered for 2 weeks at either 25 mg/kg per day or 50 mg/kg per day (ISO25 or ISO50) via a subcutaneously implanted osmotic mini-pump to either control rats or those receiving ginseng (0.9 g/L in the drinking water ad libitum). Isoproterenol produced time- and dose-dependent left ventricular dysfunction, although these effects were attenuated by ginseng. Improved cardiac functions were associated with reduced heart masses, as well as prevention in the upregulation of the hypertrophy-related fetal gene expression. Lung masses were similarly attenuated, suggesting reduced pulmonary congestion. In in vitro studies, ginseng (10 μg/mL) completely suppressed the hypertrophic response to 1 μmol/L isoproterenol in terms of myocyte surface area, as well as reduction in the upregulation of fetal gene expression. These effects were associated with attenuation in both protein kinase A and cAMP response element-binding protein phosphorylation. Ginseng attenuates adverse cardiac adrenergic responses and, therefore, may be an effective therapy to reduce hypertrophy and heart failure associated with excessive catecholamine production. |
| Databáze: | OpenAIRE |
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