An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity
| Autor: | Jia-Hao Liang, Xiao-Peng Deng, Ying-Ying Wu, Jian-Chao Zhao, Xiaokui Huo, Yi-Xuan Zhang, Zhongbin Cheng, Tian-Mei Yang, Tian-Yuan Zhang, Cheng-Peng Sun, Xiao-Hui Kang, Zhong-Jian Chen |
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| Rok vydání: | 2018 |
| Předmět: |
Indole test
biology 010405 organic chemistry Chemistry Stereochemistry Electrospray ionization Organic Chemistry Bacillus cereus Plant Science medicine.disease Antimicrobial biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Peptide deformylase medicine Panax notoginseng Klebsiella pneumonia Candida albicans |
| Zdroj: | Natural Product Research. 33:2770-2776 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | One new indole diterpenoid, drechmerin I (1), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng. Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (1) was assayed for its antimicrobial activity against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin I (1) showed antimicrobial activities against B. subtillis with an MIC value of 200 μg/mL. The interaction of S. aureus peptide deformylase with drechmerin I (1) was investigated by molecular docking. |
| Databáze: | OpenAIRE |
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