The quest for mammalian Polycomb response elements: are we there yet?
| Autor: | Leonie Ringrose, Moritz Bauer, Johanna Trupke |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Chromosomal Proteins Non-Histone Polycomb-Group Proteins Review Trithorax Response Elements DNA-binding protein DNA sequencing Mammal Histones 03 medical and health sciences Mice Genetics Polycomb-group proteins Animals Drosophila Proteins Humans Genetics(clinical) Epigenetics Gene Drosophila Genetics (clinical) Polycomb response element Polycomb Repressive Complex 1 biology fungi Genes Homeobox Polycomb Repressive Complex 2 biology.organism_classification Polycomb DNA-Binding Proteins 030104 developmental biology Histone Drosophila melanogaster Evolutionary biology biology.protein CpG Islands Protein Processing Post-Translational Transcription Factors |
| Zdroj: | Chromosoma |
| ISSN: | 1432-0886 0009-5915 |
| Popis: | A long-standing mystery in the field of Polycomb and Trithorax regulation is how these proteins, which are highly conserved between flies and mammals, can regulate several hundred equally highly conserved target genes, but recognise these targets via cis-regulatory elements that appear to show no conservation in their DNA sequence. These elements, termed Polycomb/Trithorax response elements (PRE/TREs or PREs), are relatively well characterised in flies, but their mammalian counterparts have proved to be extremely difficult to identify. Recent progress in this endeavour has generated a wealth of data and raised several intriguing questions. Here, we ask why and to what extent mammalian PREs are so different to those of the fly. We review recent advances, evaluate current models and identify open questions in the quest for mammalian PREs. Electronic supplementary material The online version of this article (doi:10.1007/s00412-015-0539-4) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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