Insular carcinoma of the thyroid with uncommon cytologic features: anisokaryotic cells and microfollicles containing dense colloid
Autor: | Suna Erkiliç, N. Emrah Koçer |
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Rok vydání: | 2005 |
Předmět: |
endocrine system
medicine.medical_specialty Pathology Biopsy Fine-Needle Thyroglobulin Pathology and Forensic Medicine Lesion Diagnosis Differential Colloid Cytology medicine Neoplasm Humans Thyroid Neoplasms Ultrasonography Cell Nucleus medicine.diagnostic_test business.industry Thyroid Nodule (medicine) Cell Biology Middle Aged medicine.disease Adenocarcinoma Mucinous Immunohistochemistry Fine-needle aspiration medicine.anatomical_structure Cytopathology Thyroidectomy Keratins Female Radiology medicine.symptom business |
Zdroj: | Pathology, research and practice. 202(5) |
ISSN: | 0344-0338 |
Popis: | Insular carcinoma of the thyroid is a rare neoplasm, constituting less than 5% of all thyroid tumors. It was Carcangiu et al. who first described this tumor, which exhibits an intermediate biologic behavior between well-differentiated and undifferentiated follicular carcinomas, as a distinct clinicopathologic entity. A 63-year-old female patient with thyroid enlargement was admitted to our institution. Thyroid ultrasonography revealed a 5×4×3 cm solid nodule within the right thyroid lobe. The fine needle aspiration was highly cellular; there were individual cells with naked nuclei, loose aggregates, cohesive clusters of follicular cells and infrequent microfollicles with round-oval nuclei containing finely granular chromatin, and scant cytoplasm. There were two uncommon findings not previously reported in the literature. The first one is anisokaryotic nuclei, and the second one is the presence of dense colloid in the center of microfollicles. The aspiration biopsy was reported as malignant. The patient underwent bilateral total thyroidectomy. Histopathologically, the lesion was diagnosed as insular carcinoma. We believe that in addition to the previously described cytopathologic findings, microfollicles with dense colloid core and anisokaryosis may be indicators of insular carcinoma in thyroid FNACs. |
Databáze: | OpenAIRE |
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