Baseline Troponin T level in stroke and its association with stress cardiomyopathy
| Autor: | Marcel Arnold, Mirjam Rachel Heldner, Urs Fischer, Julia Anne Meisterernst, Kety Hsieh, Heinrich Mattle, Verma Rajeev, Tomas Dobrocky, Erick Siqueira, Kai Timo Liesirova, Eugenio Abela, Thomas Pilgrim, Jan Gralla, Simon Jung, Thomas Raphael Meinel, Laura Bickel, Hakan Sarikaya, Marwan El-Koussy |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Myocardial Infarction Cardiomyopathy Cardiovascular Medicine 030204 cardiovascular system & hematology Pathology and Laboratory Medicine Vascular Medicine Biochemistry Diagnostic Radiology Electrocardiography 0302 clinical medicine Medicine and Health Sciences ST segment Prospective Studies Myocardial infarction Cardiovascular Imaging 610 Medicine & health Stroke Aged 80 and over Multidisciplinary medicine.diagnostic_test Troponin T Radiology and Imaging Angiography Middle Aged Magnetic Resonance Imaging Bioassays and Physiological Analysis Neurology Creatinine Cardiology Medicine Female Research Article medicine.medical_specialty Imaging Techniques Science Cerebrovascular Diseases Research and Analysis Methods 03 medical and health sciences Signs and Symptoms Takotsubo Cardiomyopathy Diagnostic Medicine Internal medicine T wave medicine Humans Aged Retrospective Studies Ischemic Stroke business.industry Electrophysiological Techniques Biology and Life Sciences medicine.disease Lesions Cardiac Electrophysiology business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | PLoS ONE Liesirova, Kai Timo; Abela, Eugenio; Pilgrim, Thomas; Bickel, Laura; Meinel, Thomas Raphael; Meisterernst, Julia Anne; Verma, Rajeev Kumar; Sarikaya, Hakan; Heldner, Mirjam Rachel; Dobrocky, Tomas; Siqueira, E.; El-Koussy, Marwan; Fischer, Urs; Gralla, Jan; Arnold, Marcel; Mattle, Heinrich; Hsieh, Kety Wha-Vei; Jung, Simon (2018). Baseline Troponin T level in stroke and its association with stress cardiomyopathy. PLoS ONE, 13(12), e0209764. Public Library of Science 10.1371/journal.pone.0209764 PLoS ONE, Vol 13, Iss 12, p e0209764 (2018) |
| ISSN: | 1932-6203 |
| Popis: | BackgroundDifferential diagnosis of elevated high sensitive Troponin T (hsTnT) in acute ischemic stroke includes myocardial infarction (MI) and neurogenic stunned myocardium (NSM). The aim of this study was to identify factors associated with baseline hsTnT levels and MI or NSM in acute ischemic stroke.MethodsWe studied 204 consecutive patients of the prospective acquired Bern Stroke Database with acute ischemic stroke diagnosed by brain MR. All patient histories and cardiac examinations were reviewed retrospectively. Volumetry of lesions on diffusion and perfusion weighted brain imaging (circular singular value decomposition, Tmax >6sec) was performed. Voxel based analysis was performed to identify brain areas associated with hsTnT elevation. Linear regression analysis was used to identify predictors of baseline hsTnT levels and myocardial infarction.ResultsElevated hsTnT was observed in 58 of the 204 patients (28.4%). The mean age was 68.3 years in the normal hsTnT group and 69.7 years in the elevated hsTnT group. Creatinine (pConclusionElevated baseline baseline hsTnT was associated with NIHSS, creatinine, ST segment depression and inverted T waves, but not with stroke location or size. None of the factors was helpful to differentiate MI and NSM. Therefore, ancillary investigations such as coronary angiography, cardiac MRI or both may be needed to solve the differential diagnosis. |
| Databáze: | OpenAIRE |
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