Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort
Autor: | Alan S. Brown, Andre Sourander, Hans Helenius, Mika Gissler, Venla Lehti, Katja M. Lampi, Susanna Hinkka-Yli-Salomäki |
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Rok vydání: | 2013 |
Předmět: |
Adult
Male Parents Risk Pediatrics medicine.medical_specialty Adolescent Offspring behavioral disciplines and activities Paternal Age Young Adult Pregnancy mental disorders Prevalence Developmental and Educational Psychology Pervasive developmental disorder medicine Humans Advanced maternal age Young adult Child Finland Aged Teenage pregnancy Middle Aged medicine.disease Logistic Models Child Development Disorders Pervasive Case-Control Studies Child Preschool Autism Female Psychology Maternal Age Cohort study |
Zdroj: | Journal of Autism and Developmental Disorders. 43:2526-2535 |
ISSN: | 1573-3432 0162-3257 |
Popis: | Aim of the study was to examine the associations between parental age and autism spectrum disorders (ASD). Data were based on the FIPS-A (Finnish Prenatal Study of Autism and Autism Spectrum Disorders), a case-control study with a total of 4,713 cases with childhood autism (n = 1,132), Asperger's syndrome (n = 1,785) or other pervasive developmental disorder (PDD) (n = 1,796), which were ascertained from the Finnish Hospital Discharge Register. Controls were selected from the Finnish Medical Birth Register. Conditional logistic regression models were used for statistical analyses. Advanced paternal age (35-49 years) was associated with childhood autism in offspring, whereas advanced maternal age was associated with both Asperger's syndrome and PDD in offspring (35 years or more and 40 years or more, respectively). Teenage motherhood (19 years or less) was associated with PDD in offspring. The main finding was that maternal and paternal ages were differentially associated with ASD subtypes. In addition to advanced parental age, teenage pregnancy seems to incur a risk for PDD in offspring. |
Databáze: | OpenAIRE |
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