Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline
| Autor: | Sarah L. Berga, M. Hassan Murad, Jay R. Kaplan, Nanette Santoro, Madhusmita Misra, Michelle P. Warren, Catherine M. Gordon, George Mastorakos, Kathryn E. Ackerman |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Clinical Biochemistry Reproductive medicine MEDLINE 030209 endocrinology & metabolism Anorexia nervosa Biochemistry Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Humans Amenorrhea Societies Medical Evidence-Based Medicine 030219 obstetrics & reproductive medicine business.industry Biochemistry (medical) Guideline Evidence-based medicine medicine.disease Mental health Diagnosis of exclusion Systematic review Reproductive Medicine Female business Hypothalamic Diseases |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 102:1413-1439 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2017-00131 |
| Popis: | Cosponsoring associations The American Society for Reproductive Medicine, the European Society of Endocrinology, and the Pediatric Endocrine Society. This guideline was funded by the Endocrine Society. Objective To formulate clinical practice guidelines for the diagnosis and treatment of functional hypothalamic amenorrhea (FHA). Participants The participants include an Endocrine Society-appointed task force of eight experts, a methodologist, and a medical writer. Evidence This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence. The task force commissioned two systematic reviews and used the best available evidence from other published systematic reviews and individual studies. Consensus process One group meeting, several conference calls, and e-mail communications enabled consensus. Endocrine Society committees and members and cosponsoring organizations reviewed and commented on preliminary drafts of this guideline. Conclusions FHA is a form of chronic anovulation, not due to identifiable organic causes, but often associated with stress, weight loss, excessive exercise, or a combination thereof. Investigations should include assessment of systemic and endocrinologic etiologies, as FHA is a diagnosis of exclusion. A multidisciplinary treatment approach is necessary, including medical, dietary, and mental health support. Medical complications include, among others, bone loss and infertility, and appropriate therapies are under debate and investigation. |
| Databáze: | OpenAIRE |
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