Development and Evaluation of Orodispersible Tablets Containing Ketoprofen
| Autor: | Maria da Graça T. Toledo, Laiane J. Oliveira, Itamar Francisco Andreazza, Aline Carolina Cunha, Fábio S. Murakami, Andressa Veiga, Nayana C. F. Stofella |
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| Rok vydání: | 2019 |
| Předmět: |
Ketoprofen
Quality Control Materials science Time Factors Surface Properties Drug Compounding Pharmaceutical Science Administration Oral 02 engineering and technology Friability 030226 pharmacology & pharmacy Dosage form 03 medical and health sciences Granulation Starch glycolate Freeze-drying 0302 clinical medicine Drug Development medicine Humans Water intake Particle Size 021001 nanoscience & nanotechnology Solubility 0210 nano-technology Flow properties medicine.drug Biomedical engineering Tablets |
| Zdroj: | Current drug delivery. 17(4) |
| ISSN: | 1875-5704 |
| Popis: | Background: Orodispersible Tablets (ODTs) are an option to facilitate the intake of pharmaceutical solid dosage forms, which dissolve in the mouth within 30 seconds releasing the drug immediately with no need for water intake or chewing. Objective: The main goal of our study is the technological development of lactose-free orodispersible tablets that contain ketoprofen. Methods: We assessed different variables during the pharmaceutical development of ODTs: compression techniques conducted after a wet granulation process, aiming to optimize the flow properties of the formulation, and a suspension freeze-drying molded in blisters. We developed three formulations for each method, each containing one of the superdisintegrants: croscarmellose, crospovidone, or starch glycolate. Result: During the production of ODTs, we performed quality control of the granulation process, since the production of pellets contributed to the enhancement of the disintegration time and content homogeneity. Quality control tests for ODTs produced by freeze-drying were also satisfactory, despite significant changes in the final physical aspect of these products when compared to that of ODTs produced by compression. In addition, the disintegration times of ODTs produced by freeze-drying were substantially higher. Furthermore, these tablets displayed greater friability and pose a challenge to the control of a standard individual weight. Conclusion: Among the superdisintegrants, croscarmellose contributed most significantly to reduce the disintegration time and to dissolve KTP effectively in 20 minutes. |
| Databáze: | OpenAIRE |
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