Degenerative changes in the internal elastic lamina relating to the development of saccular cerebral aneurysms in rats
| Autor: | Jorge Cervós-Navarro, F. Hazama, Ch. Kim, Haruhiko Kikuchi, Nobuo Hashimoto |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Lamina Pathology medicine.medical_specialty Cerebral arteries Muscle Smooth Vascular Rats Sprague-Dawley Aneurysm medicine.artery medicine Anterior cerebral artery Animals skin and connective tissue diseases business.industry Intracranial Aneurysm Anatomy Internal elastic lamina medicine.disease Tunica intima Elastic Tissue Apex (geometry) Rats Disease Models Animal Microscopy Electron medicine.anatomical_structure cardiovascular system Surgery sense organs Neurology (clinical) business Tunica Intima Artery |
| Zdroj: | Acta neurochirurgica. 121(1-2) |
| ISSN: | 0001-6268 |
| Popis: | In order to investigate the developmental mechanism of saccular cerebral aneurysms, changes in the internal elastic lamina at the junction of the anterior cerebral artery and the olfactory artery were electronmicroscopically studied in 6 control and 6 experimental rats undergoing ligation of the left carotid artery and branches of both renal arteries. In the control group, spontaneous destructive changes occurred on the luminal side of the internal elastic lamina and progressed from the luminal towards the abluminal side as the elastic lamina advanced to the apex. Close to the apex, these changes invaded and disrupted the whole elastic lamina. The elastic lamina was replaced by sparsely lined up lumps of elastic tissue in the walls of early aneurysmal alterations, and was atrophied and disappeared totally in the walls of aneurysmal alterations that had reached an advanced stage. These spontaneous changes were in agreement with reports in the literature and our own previous investigations. From the findings in the experimental rats it becomes likely that the aneurysmal changes in the elastic lamina are exaggerated forms of the normal catabolic metabolism. Therefore its synthesis on the abluminal side no longer balances with the catabolism on the luminal side. It is strongly suggested that aneurysmal alterations progress from the luminal towards the abluminal side of arterial walls and that the lytic process of elastase might play a role in the degenerative changes in aneurysmal development. |
| Databáze: | OpenAIRE |
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