Vascular reactivity to angiotensin II in the normotensive and hypertensive pregnant ewe
| Autor: | T. Cabalum, B. Nuwayhid, Nicholas S. Assali, E. Ushioda, Marcelo Zugaib, Stephen M. Lieb, Charles R. Brinkman, R. Erkkola, Khalil Tabsh |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Hypertension Renal Physiology Pregnancy Complications Cardiovascular Blood Pressure Kidney Pregnancy Physiology (medical) Internal medicine Renin–angiotensin system medicine Animals Sheep Renal circulation Dose-Response Relationship Drug business.industry Angiotensin II Uterus Blood flow medicine.disease medicine.anatomical_structure Endocrinology Regional Blood Flow Renal blood flow Pathophysiology of hypertension Circulatory system Vascular resistance Pregnancy Animal Female Vascular Resistance Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 238:H209-H213 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.1980.238.2.h209 |
| Popis: | The circulatory responses to progressively increasing doses of angiotensin II were studied in the same group of chronically instrumented unanesthetized pregnant sheep during three consecutive periods: a) normotensive with intact kidneys; b) normotensive with unilateral nephrectomy; and c) one-kidney hypertension. The results show that 1) the pressor response to a given dose of angiotensin was significantly greater in the normotensive than in the hypertensive condition; 2) uterine blood flow decreased markedly with the development of hypertension; 3) uterine circulatory response to angiotensin depended on the dosage; the response was less the the hypertensive than in the normotensive condition; 4) renal blood flow decreased and renal vascular resistance increased during angiotensin infusion, but the response was less in the hypertensive than in the normotensive condition; the response of the renal circulation decreased with increasing doses of angiotensin. These observations suggest a generalized vascular refractoriness to exogenous angiotensin II in the pregnant ewe with experimental renal hypertension. |
| Databáze: | OpenAIRE |
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