Characterization of a novel member of the FGFR family, HrFGFR, in Halocynthia roretzi
| Autor: | Shuichi Kamei, Takahiro Kunisada, Hiroaki Yamamoto, Ichiro Yajima, Shin-Ichi Hayashi, Ako Kobayashi, Kazuhiro W. Makabe, Hidetoshi Yamazaki |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
animal structures
DNA Complementary Xenopus Molecular Sequence Data Biophysics Biology Biochemistry Complementary DNA Animals Amino Acid Sequence Urochordata Cloning Molecular Molecular Biology Gene Peptide sequence In Situ Hybridization Base Sequence Sequence Homology Amino Acid cDNA library Cell Biology biology.organism_classification Molecular biology Receptors Fibroblast Growth Factor Restriction site Neurula Fibroblast growth factor receptor embryonic structures |
| Zdroj: | Biochemical and biophysical research communications. 275(2) |
| ISSN: | 0006-291X |
| Popis: | The cDNA for a novel member of the FGFR family, named HrFGFR, was isolated from a Halocynthia roretzi cDNA library prepared at the mid-tailbud stage. This cDNA was 3507b long, and the deduced amino acid sequence contained a motif characteristic of the vertebrate FGFRs. The existence of a single copy of the FGFR homologue gene in H. roretzi was suggested by restriction site analysis of multiple clones. HrFGFR mRNA was expressed strongly in the posterior region in the epidermis from the middle neurula stage. By contrast, Xenopus FGFR homologues are expressed in the anterior region and are known to induce anterior neural formation. A transition of the region expressing FGFR might have induced the more complicated brain or head formation characteristic of vertebrates. |
| Databáze: | OpenAIRE |
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