Urine NGAL and KIM-1: tubular injury markers in acute lymphoblastic leukemia survivors

Autor: Maryna Krawczuk-Rybak, Katarzyna Taranta-Janusz, Katarzyna Konończuk, Anna Wasilewska, Edyta Szymczak, Katarzyna Muszyńska-Rosłan, Eryk Latoch
Rok vydání: 2020
Předmět:
Male
Cancer Research
030232 urology & nephrology
Urine
Acute lymphoblastic leukemia
Toxicology
Gastroenterology
Childhood cancer survivors
chemistry.chemical_compound
0302 clinical medicine
Cancer Survivors
Medicine
Pharmacology (medical)
Hepatitis A Virus Cellular Receptor 1
Child
Cumulative dose
Acute kidney injury
Acute Kidney Injury
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Total body irradiation
Urine KIM-1
Oncology
Child
Preschool
030220 oncology & carcinogenesis
Original Article
Female
Chronic kidney diseases
medicine.medical_specialty
Adolescent
Urinary system
Antineoplastic Agents
Urine NGAL
Nephrotoxicity
Young Adult
03 medical and health sciences
Lipocalin-2
Internal medicine
Humans
Renal Insufficiency
Chronic
Pharmacology
Creatinine
business.industry
Infant
medicine.disease
CCS
chemistry
Case-Control Studies
business
Biomarkers
Follow-Up Studies
Kidney disease
Zdroj: Cancer Chemotherapy and Pharmacology
ISSN: 1432-0843
0344-5704
Popis: Introduction Nephrotoxicity is a potential adverse effect of anticancer treatment in childhood. Cytostatics, abdominal radiotherapy, total body irradiation (TBI) and some agents used in supportive care may induce acute kidney injury (AKI) or lead to chronic kidney disease (CKD). The aim of this study was to test the hypothesis whether urinary kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are increased in acute lymphoblastic leukemia (ALL) survivors. Method The study cohort consisted of 86 patients (42 females) previously treated for ALL. The median time after cessation of treatment was 6.55 (IQR: 1.96–9.93) years and median age at the time of study: 12 (IQR: 6.76–16.00). The control group included 53 healthy peers. Immunoenzymatic ELISA commercial kits were used to measure urine KIM-1 and NGAL levels. Results The median levels of urine uNGAL (p p p 2. The NGAL/cr. ratio seemed to be the best predictor of decreased eGFR (AUC = 0.65). The cumulative dose of methotrexate and cyclophosphamide did not predict the values of the urine NGAL, NGAL/cr., KIM-1/cr. and eGFR. Five years after the end of treatment, the patients had higher levels of uKIM-1 (1.02 ± 0.8 vs. 0.62 ± 0.6 ng/mL, p p 2, p Conclusion We demonstrated that ALL survivors have higher levels of urine NGAL, NGAL/cr. and uKIM-1/cr. ratio as compared to the control group. Further long-term follow-up studies are necessary to assess the significance of the NGAL and KIM-1 and their relationship to kidney damage after anticancer treatment in childhood.
Databáze: OpenAIRE
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