Fe(III) salEen derived Schiff base complexes as potential contrast agents
| Autor: | Stephen J. Keely, Ana I. Vicente, Sónia Barroso, Joseph B. J. Ward, Pedro J. Sebastião, Bernardo de P. Cardoso, A. Carvalho, Fabián Vaca Chávez, Maria José Calhorda, Paulo N. Martinho |
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| Rok vydání: | 2015 |
| Předmět: |
Biological studies
Schiff base Proton Chemistry Stereochemistry CELL TOXICITY Otras Ciencias Químicas Relaxation (NMR) Ciencias Químicas EVANS' METHOD Crystal structure CONTRAST AGENT NMRD Medicinal chemistry Inorganic Chemistry Paramagnetism chemistry.chemical_compound Monolayer Materials Chemistry FE(III) COMPLEXES Phenyl group Physical and Theoretical Chemistry CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | Inorganica Chimica Acta. 432:258-266 |
| ISSN: | 0020-1693 |
| DOI: | 10.1016/j.ica.2015.04.026 |
| Popis: | Three iron(III) complexes with ligands derived from N-ethyl-N-(2-aminoethyl)salicylaldiminate (H, 1; 5-Br, 2; 3-OMe, 3 substituents at the phenyl group) were prepared and the X-ray crystal structures of 1 and 2 are reported. NMR studies of solutions of these complexes in DMSO allowed for investigation of their magnetic behaviour and paramagnetic relaxation contribution. The relaxivities measured ranged from 0.35 to 0.80 mM-1 s-1 for proton Larmor frequencies from 0.01 to 300 MHz, in agreement with those known for other iron(III) based contrast agents. Biological studies on colonic epithelial T84 cell monolayers showed that the compounds exert toxic effects only at concentrations higher than 100 μM while coincidently reducing colonic epithelial secretory function. These two features make these complexes good candidates for further development in order to be used as MRI contrast agents. Fil: Cardoso, Bernardo de P.. Universidade de Lisboa; Portugal Fil: Vicente, Ana I.. Universidade de Lisboa; Portugal Fil: Ward, Joseph B. J.. Beaumont Hospital; Irlanda Fil: Sebastião, Pedro J.. Universidade de Lisboa; Portugal Fil: Vaca Chávez Fornasero, Fabián. Universidade de Lisboa; Portugal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina Fil: Barroso, Sónia. Universidade de Lisboa; Portugal Fil: Carvalho, Alexandra. Universidade Nova de Lisboa; Portugal Fil: Keely, Stephen J.. Beaumont Hospital; Irlanda Fil: Martinho, Paulo N.. Universidade de Lisboa; Portugal Fil: Calhorda, Maria José. Universidade de Lisboa; Portugal |
| Databáze: | OpenAIRE |
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