The protective effects of different treatments on rat salivary glands after radiotherapy
| Autor: | Atila Gungor, Mesut Mutluoglu, Murat Konak, Volkan Arisan, Hakan Cincik, Murat Salihoglu, Zafer Kucukodaci, Evren Erkul, Engin Cekin, Sevim Ozdemir |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology medicine.medical_specialty Ductal cells medicine.drug_class N-Acetylcysteine Radiation-Protective Agents Radiation Dosage Dexamethasone Salivary Glands 030218 nuclear medicine & medical imaging Random Allocation 03 medical and health sciences 0302 clinical medicine medicine Acinar cell Corticosteroid Animals Parotid Gland Hyperbaric Oxygen Rats Wistar Glucocorticoids Hyperbaric Oxygenation Radiotherapy Salivary gland business.industry General Medicine Acetylcysteine Rats Parotid gland Radiation Injuries Experimental medicine.anatomical_structure Otorhinolaryngology Vacuolization 030220 oncology & carcinogenesis business Pyknosis medicine.drug |
| Zdroj: | European Archives of Oto-Rhino-Laryngology. 273:4501-4506 |
| ISSN: | 1434-4726 0937-4477 |
| DOI: | 10.1007/s00405-016-4159-2 |
| Popis: | WOS: 000387700400056 PubMed ID: 27324888 This study was aimed to evaluate the efficacy of treatment modalities for minimizing salivary gland damage caused by radiotherapy. Forty rats were divided into five groups. Group 1 had no irradiation or any treatment. Group 2 underwent only 15 Gy single dose radiotherapy. N-acetylcysteine, dexamethasone, hyperbaric oxygen treatment were given, respectively to the group 3, 4 and 5 for 5 days. 15 Gy single dose radiotherapy was applied to the group 3, 4 and 5 on the second day. Pyknosis, lysis, and vacuolization were examined in ductal cells and pyknosis, lysis, vacuolization, inflammation and collective duct damage in acinar cells. Dexamethasone and hyperbaric oxygen did not prove to have a positive effect on acinar and ductal cell. N-acetylcysteine-applied group had statistically significantly lower amount of damage. We determined that the decrease of ductal and acinar cell damage in parotid glands of N-acetylcysteine-applied rats was more distinct and statistically. |
| Databáze: | OpenAIRE |
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