Acute and Chronic Dopaminergic Depletion Differently Affect Motor Thalamic Function
| Autor: | Agnese Salvadè, Salvatore Galati, Alain Kaelin-Lang, Giuseppe Di Giovanni, Ernesto Fedele, Wei Song, Alessandro Stefani, Eleonora Cuboni, Laura Clara Grandi, Gergely Orban |
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| Přispěvatelé: | Di Giovanni, G, Grandi, L, Fedele, E, Orban, G, Salvade, A, Song, W, Cuboni, E, Stefani, A, Kaelin-Lang, A, Galati, S |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Dopamine Dopamine Agents L-DOPA Dopaminergic neurons Basal Ganglia Levodopa Rats Sprague-Dawley lcsh:Chemistry chemistry.chemical_compound 0302 clinical medicine Thalamus Basal ganglia Deep brain stimulation Premovement neuronal activity deep brainstimulation 610 Medicine & health Medial forebrain bundle lcsh:QH301-705.5 gamma-Aminobutyric Acid Spectroscopy Cerebral Cortex Neurons Dopaminergic Glutamate receptor General Medicine deep brain stimulation Computer Science Applications Microdialysi L DOPA immunohistochemistry Tetrodotoxin medicine.drug Thalamus -- Differentiation medicine.medical_specialty microdialysis Glutamic Acid Settore MED/26 Article Catalysis Inorganic Chemistry 03 medical and health sciences Adrenergic Agents Internal medicine medicine Animals Physical and Theoretical Chemistry Oxidopamine Molecular Biology GABAergic neurons fungi Organic Chemistry Medial Forebrain Bundle electrophysiology microdialysis immunohistochemistry L DOPA deep brainstimulation electrophysiology Rats Electrophysiology 030104 developmental biology Endocrinology lcsh:Biology (General) lcsh:QD1-999 nervous system chemistry 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 2734, p 2734 (2020) International Journal of Molecular Sciences Volume 21 Issue 8 Di Giovanni, Giuseppe; Grandi, Laura Clara; Fedele, Ernesto; Orban, Gergely; Salvadè, Agnese; Song, Wei; Cuboni, Eleonora; Stefani, Alessandro; Kaelin-Lang, Alain; Galati, Salvatore (2020). Acute and Chronic Dopaminergic Depletion Differently Affect Motor Thalamic Function. International journal of molecular sciences, 21(8) MDPI 10.3390/ijms21082734 |
| Popis: | The motor thalamus (MTh) plays a crucial role in the basal ganglia (BG)-cortical loop in motor information codification. Despite this, there is limited evidence of MTh functionality in normal and Parkinsonian conditions. To shed light on the functional properties of the MTh, we examined the effects of acute and chronic dopamine (DA) depletion on the neuronal firing of MTh neurons, cortical/MTh interplay and MTh extracellular concentrations of glutamate (GLU) and gamma-aminobutyric acid (GABA) in two states of DA depletion: acute depletion induced by the tetrodotoxin (TTX) and chronic denervation obtained by 6-hydroxydopamine (6-OHDA), both infused into the medial forebrain bundle (MFB) in anesthetized rats. The acute TTX DA depletion caused a clear-cut reduction in MTh neuronal activity without changes in burst content, whereas the chronic 6-OHDA depletion did not modify the firing rate but increased the burst firing. The phase correlation analysis underscored that the 6-OHDA chronic DA depletion affected the MTh-cortical activity coupling compared to the acute TTX-induced DA depletion state. The TTX acute DA depletion caused a clear-cut increase of the MTh GABA concentration and no change of GLU levels. On the other hand, the 6-OHDA-induced chronic DA depletion led to a significant reduction of local GABA and an increase of GLU levels in the MTh. These data show that MTh is affected by DA depletion and support the hypothesis that a rebalancing of MTh in the chronic condition counterbalances the profound alteration arising after acute DA depletion state peer-reviewed |
| Databáze: | OpenAIRE |
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