Small Molecule Inhibitors Targeting Key Proteins in the DNA Damage Response for Cancer Therapy
| Autor: | Zhigang Guo, Lulu Li, Zhigang Hu, Alagamuthu Karthick Kumar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Genome instability
DNA Repair Combination therapy DNA damage DNA repair 01 natural sciences Biochemistry Genomic Instability 03 medical and health sciences Neoplasms Drug Discovery Humans Medicine 0101 mathematics 030304 developmental biology Pharmacology 0303 health sciences business.industry Organic Chemistry DNA Repair Pathway Small molecule body regions 010101 applied mathematics Drug repositioning Cancer cell Cancer research Molecular Medicine business DNA Damage |
| Zdroj: | Current Medicinal Chemistry. 28:963-985 |
| ISSN: | 0929-8673 |
| DOI: | 10.2174/0929867327666200224102309 |
| Popis: | DNA damage response (DDR) is a complicated interactional pathway. Defects that occur in subordinate pathways of the DDR pathway can lead to genomic instability and cancer susceptibility. Abnormal expression of some proteins in DDR, especially in the DNA repair pathway, are associated with the subsistence and resistance of cancer cells. Therefore, the development of small molecule inhibitors targeting the chief proteins in the DDR pathway is an effective strategy for cancer therapy. In this review, we summarize the development of small molecule inhibitors targeting chief proteins in the DDR pathway, particularly focusing on their implications for cancer therapy. We present the action mode of DDR molecule inhibitors in preclinical studies and clinical cancer therapy, including monotherapy and combination therapy with chemotherapeutic drugs or checkpoint suppression therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|