The effect of restraint stress on paradoxical sleep is influenced by the circadian cycle

Autor: M. Le Moal, Muriel Darnaudéry, J.J. Bouyer, Muriel Koehl, Willy Mayo
Přispěvatelé: INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale, F-33000 Bordeaux, France, Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2002
Předmět:
Male
Light
MESH: Rats
Sprague-Dawley
Rats
Sprague-Dawley
0302 clinical medicine
Homeostasis
MESH: Animals
MESH: Stress
Physiological
Slow-wave sleep
0303 health sciences
General Neuroscience
MESH: Darkness
Electroencephalography
Darkness
MESH: Restraint
Physical
Sleep in non-human animals
Circadian Rhythm
MESH: Homeostasis
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Wakefulness
Psychology
Restraint
Physical
medicine.medical_specialty
MESH: Rats
Photoperiod
Period (gene)
Rapid eye movement sleep
Sleep
REM
MESH: Photoperiod
Immobilization
03 medical and health sciences
Stress
Physiological
Internal medicine
MESH: Electroencephalography
Reaction Time
medicine
Animals
Free-running sleep
MESH: Circadian Rhythm
Circadian rhythm
Molecular Biology
030304 developmental biology
Stressor
MESH: Sleep
REM
MESH: Immobilization
MESH: Light
MESH: Male
Rats
MESH: Reaction Time
MESH: Wakefulness
Endocrinology
Neurology (clinical)
Neuroscience
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Brain Research
Brain Research, Elsevier, 2002, 937 (1-2), pp.45-50. ⟨10.1016/s0006-8993(02)02463-0⟩
Brain Research, 2002, 937 (1-2), pp.45-50. ⟨10.1016/s0006-8993(02)02463-0⟩
ISSN: 0006-8993
Popis: International audience; It is well known that the physiological impact imposed by events or behaviors displayed during the waking period determines the way organisms sleep. Among the situations known to affect sleep both in its duration and quality, stress has been widely studied and it is now admitted that its effects on sleep architecture depend on several factors specific to the stressor or the individual itself. Although numerous reports have highlighted the prominent role of the circadian cycle in the physiological, endocrine and behavioral consequences of restraint stress, a possible circadian influence in the effects of stress on the sleep-wake cycle has never been studied. Thus the present study was designed to compare the effects on sleep of a 1 h-lasting restraint stress applied at light onset to those observed after the same stressor was applied at light offset. We report that in both conditions stress induced a marked paradoxical sleep increase, whereas wakefulness displayed a moderate decrease and slow wave sleep a moderate augmentation. Although the effects of stress at lights on were of similar magnitude than those of stress at lights off, important differences in the sleep rebound latencies were observed: whatever the time of day the stress was applied, its effects on sleep always occurred during the dark period. This result thus shows that restraint stress could be efficiently used to study the interaction between the circadian and homeostatic components of sleep regulation.
Databáze: OpenAIRE
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