Well-Defined NNS-Mn Complex Catalyzed Selective Synthesis of C-3 Alkylated Indoles and Bisindolylmethanes Using Alcohols

Autor:	Avijit Mondal, Rahul Sharma, Bishal Dutta, Debjyoti Pal, Dipankar Srimani
Rok vydání:	2022
Předmět:	Indoles Ethanol Organic Chemistry Methane Catalysis
Zdroj:	The Journal of Organic Chemistry. 87:3989-4000
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.1c02702
Popis:	Herein, we demonstrated Mn-catalyzed selective C-3 functionalization of indoles with alcohols. The developed catalyst can also furnish bis(indolyl)methanes from the same set of substrates under slightly modified reaction conditions. Mechanistic studies reveal that the C-3 functionalization of indoles is going via a borrowing hydrogen pathway. To highlight the practical utility, a diverse range of substrates including nine structurally important drug molecules are synthesized. Furthermore, we also introduced a one-pot cascade strategy for synthesizing C-3 functionalized indoles directly from 2-aminophenyl ethanol and alcohol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1db1a156c4f72ce12f46a1d36e0069 https://doi.org/10.1021/acs.joc.1c02702 Zobrazit plný text záznamu