Two cases of neuroangiostrongyliasis: A rare disease because rarely considered or rarely diagnosed?
| Autor: | Leslie T Anthony, Anthony Herbert, Angela Berkhout, Clare Nourse, Paul Prociv |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Eosinophilic Meningitis Disease 03 medical and health sciences Rare Diseases 0302 clinical medicine Central Nervous System Diseases 030225 pediatrics Epidemiology medicine Animals Humans 030212 general & internal medicine Pica (disorder) Child Strongylida Infections business.industry Mortality rate Public health Angiostrongylus cantonensis medicine.disease Child Preschool Pediatrics Perinatology and Child Health Female Queensland medicine.symptom business Encephalitis Rare disease |
| Zdroj: | Journal of Paediatrics and Child Health. 55:1463-1469 |
| ISSN: | 1440-1754 1034-4810 |
| DOI: | 10.1111/jpc.14461 |
| Popis: | Aim: The rat lungworm, Angiostrongylus cantonensis, is well established in eastern Australia, where it is the almost exclusive cause of human eosinophilic meningoencephalitis (EME). While neuroangiostrongyliasis can result in severe morbidity or death, its diagnosis requires a high index of clinical suspicion among medical practitioners. Prevention requires a high level of public awareness. Methods: We report two cases of EME in children from Queensland and summarise all reported Australian cases from the literature. We discuss the pathogenesis of neuroangiostrongyliasis, with particular reference to the timing of prophylaxis and treatment. Results: A 5-year-old girl developed severe headache, eosinophilic meningitis and abnormal neuroimaging following a holiday to Bali. A 10-year-old boy with Rubinstein-Taybi syndrome, marked developmental delay and pica developed EME following ingestion of a snail, resulting in long-term morbidity. From 1971 to 2018, 28 Australian cases have been reported, with acquisition restricted to Southeast Queensland and New South Wales. Ages ranged from 10 months to 45 years; most were male and most likely acquired infection from consuming unwashed lettuce or vegetables. The mortality rate was 18%; most fatalities occurred in children |
| Databáze: | OpenAIRE |
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