Combination therapy with gemcitabine and nab-paclitaxel for locally advanced unresectable pancreatic cancer
| Autor: | Kenichi Hakamada, Keinosuke Ishido, Takeshi Saito, Norihisa Kimura, Daisuke Kudo, Yoshihito Nakayama, Taiichi Wakiya |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Combination therapy business.industry Articles Neutropenia medicine.disease Gastroenterology Gemcitabine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Response Evaluation Criteria in Solid Tumors 030220 oncology & carcinogenesis Pancreatic cancer Internal medicine medicine CA19-9 business Adverse effect Progressive disease medicine.drug |
| Zdroj: | Molecular and Clinical Oncology. 6:963-967 |
| ISSN: | 2049-9469 2049-9450 |
| DOI: | 10.3892/mco.2017.1251 |
| Popis: | The aim of the present study was to investigate the early treatment outcomes of combined gemcitabine and nab-paclitaxel treatment for locally advanced unresectable pancreatic cancer (LURPC). The subjects comprised 7 patients with LURPC receiving the abovementioned combination therapy at the Hirosaki University Hospital (Hirosaki, Japan) between January and September, 2015. The clinicopathological factors, adverse events and response to treatment were investigated. To determine whether the cases were unresectable, the National Comprehensive Cancer Network guidelines, version 2. 201,) were applied. The patients underwent a median of 4 (range, 2-7) courses of treatment. The response to treatment was evaluated using the Response Evaluation Criteria In Solid Tumors. The subjects included 1 male and 6 female LURPC patients, with a median age of 71 years (range, 59-78 years). The tumor was located in the head and body of the pancreas in 6 and 1 patients, respectively. No patients achieved a complete response, 5 achieved a partial response, 2 had stable disease, and none exhibited progressive disease. The response rate was 71%. The mean tumor diameter decreased significantly from 35 mm (range, 24-60 mm) prior to treatment to 22 mm (range, 20-35 mm) following treatment. Two patients were downstaged. The mean carbohydrate antigen (CA) 19-9 values decreased significantly from 767 U/ml (range, 14-1,977 U/ml) prior to treatment to 35 U/ml (range, 14-123 U/ml) following treatment. Adverse events classified as grade ≥3 occurred in 4 patients (57%): 3 patients (43%) suffered from neutropenia and 1 patient (14%) developed bilateral cellulitis of the lower extremities. No patients experienced an increase in disease severity, and all were able to continue treatment following temporary withdrawal or dosage reduction. Therefore, combined treatment with gemcitabine and nab-paclitaxel had favorable tumor-reducing effects and was not associated with severe adverse events, suggesting that this is a useful therapeutic strategy for patients with LURPC. |
| Databáze: | OpenAIRE |
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