Suture Materials and Local Recurrence in Colorectal Cancer: An Experimental Study
| Autor: | R Corell Planelles, JL Salvador Sanchís, Juan Gibert-Gerez, Jesús Nomdedeu-Guinot, I Cisneros Reig, J Ruiz del Castillo |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Colon Colorectal cancer Silk Rectum Risk Assessment Rats Sprague-Dawley Random Allocation Polydioxanone chemistry.chemical_compound Reference Values Colon surgery Materials Testing Carcinoma medicine Animals Probability Titanium Chi-Square Distribution Sutures business.industry Suture Techniques Outcome measures medicine.disease University hospital Rats Surgery Disease Models Animal medicine.anatomical_structure chemistry Carcinogens Insect Proteins Neoplasm Recurrence Local Colorectal Neoplasms Complication business |
| Zdroj: | The European Journal of Surgery. 167:142-145 |
| ISSN: | 1102-4151 |
| Popis: | To investigate the carcinogenic role of suture materials in an experimental model in rats.Laboratory, experimental study.University hospital, Spain.125 Sprague-Dawley rats in 5 groups of 25 each.3 Different suture materials (silk, polydioxanone, and titanium staples) were implanted in a region of the colon in 75 rats divided into three groups of 25. Another 25 animals were injured by puncture only in the same region, and a further 25 rats were not operated on (controls). Injections of 1-2,dimethylhydrazine were then given for 26 weeks.Number of rats in each group who had tumours in the region of interest, and level of infiltration of the tumours in each group.There were no differences between the injured and control rats in the number of tumours in the study zone. All groups in which suture material had been inserted had tumours in this zone. Titanium was more carcinogenic than either silk or polydioxanone. The tumours associated with titanium were the most infiltrating.We recommend the use of absorbable sutures, with a careful follow-up of patients in whom titanium staples have been used. |
| Databáze: | OpenAIRE |
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