Undetectable serum IgA and low IgM concentration in children with congenital hypothyroidism

Autor: Chiara Azzari, G. Bindi, Fiorella Galluzzi, Stefano Stagi, Alberto Vierucci, Sergio Nanni, Roberto Salti
Rok vydání: 2005
Předmět:
Male
endocrine system
medicine.medical_specialty
endocrine system diseases
Immunology
Neonatal Screening
Immune system
Hypothyroidism
Internal medicine
Immunopathology
Congenital Hypothyroidism
Humans
Immunology and Allergy
Medicine
IgM deficiency
biology
business.industry
Some studies suggest thyroid hormones may regulate the human immune system. In order to evaluate the effect of thyroid hormone deficiency on antibody production
we evaluated serum IgA and IgM concentrations in 83 children with congenital hypothyroidism (CH)
diagnosed by neonatal screening. Patients were compared to two healthy
age-matched control groups. Patients with permanent CH had a significantly higher frequency of undetectable IgA concentrations (thyroid agenesis
P<10(-5)
thyroid ectopy
P=0.013) and lower concentrations of IgA (thyroid agenesis
P<10(-6)
thyroid ectopy
P<10(-5)
dyshormonogenesis
P=0.0002) and IgM (thyroid agenesis
P=0.0002
thyroid ectopy
P<10(-6)
dyshormonogenesis
P=0.0017) compared to control group. No difference was observed between patients with transient hypothyroidism and controls. A significant correlation was observed between serum IgA and IgM concentrations and fT4 levels. IgA and IgM deficiency is correlated with the severity of congenital hypothyroidism and may help to evaluate the duration and severity of thyroid hormone deficiency during prenatal life
Thyroid
Infant
Newborn
Infant
medicine.disease
Thyroid agenesis
Immunoglobulin A
Congenital hypothyroidism
Endocrinology
medicine.anatomical_structure
Immunoglobulin M
biology.protein
Female
Antibody
business
Biomarkers
Hormone
Zdroj: Clinical Immunology. 116:94-98
ISSN: 1521-6616
DOI: 10.1016/j.clim.2005.03.003
Popis: Some studies suggest thyroid hormones may regulate the human immune system. In order to evaluate the effect of thyroid hormone deficiency on antibody production, we evaluated serum IgA and IgM concentrations in 83 children with congenital hypothyroidism (CH), diagnosed by neonatal screening. Patients were compared to two healthy, age-matched control groups. Patients with permanent CH had a significantly higher frequency of undetectable IgA concentrations (thyroid agenesis, P < 10−5; thyroid ectopy, P = 0.013) and lower concentrations of IgA (thyroid agenesis, P < 10−6; thyroid ectopy, P < 10−5; dyshormonogenesis, P = 0.0002) and IgM (thyroid agenesis, P = 0.0002; thyroid ectopy, P < 10−6; dyshormonogenesis, P = 0.0017) compared to control group. No difference was observed between patients with transient hypothyroidism and controls. A significant correlation was observed between serum IgA and IgM concentrations and fT4 levels. IgA and IgM deficiency is correlated with the severity of congenital hypothyroidism and may help to evaluate the duration and severity of thyroid hormone deficiency during prenatal life.
Databáze: OpenAIRE
Externí odkaz: