Poor Outcome of Acute Respiratory Infection in Young Children with Underlying Health Condition in Brazil
| Autor: | Cristiane Finelli, Danielle Bruna Leal Oliveira, Reni Chehter Berezin, Giuliana Stravinskas Durigon, Juliana Gamo Storni, Maria Carolina Calahani Felicio, Maria Fernanda Badue Pereira, Edison Luiz Durigon, Raquel Negrão Caldeira, Eitan Naaman Berezin |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Risk Microbiology (medical) Pediatrics medicine.medical_specialty Acute respiratory tract infection viruses Population Respiratory Syncytial Virus Infections Respiratory virus Polymerase Chain Reaction Article Virus Adenoviridae lcsh:Infectious and parasitic diseases Adenovirus Infections Human Human metapneumovirus Intensive care Humans Mass Screening Medicine underlying disease lcsh:RC109-216 Prospective Studies Respiratory system education Children education.field_of_study Paramyxoviridae Infections DOENÇAS RESPIRATÓRIAS biology business.industry Infant Respiratory infection General Medicine Length of Stay biology.organism_classification Infectious Diseases Child Preschool Respiratory Syncytial Virus Human Acute Disease Female Metapneumovirus Seasons business Brazil |
| Zdroj: | International Journal of Infectious Diseases, Vol 34, Iss C, Pp 3-7 (2015) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP International Journal of Infectious Diseases |
| ISSN: | 1878-3511 1201-9712 |
| Popis: | Summary Objectives It is well established that respiratory viruses are an important cause of hospitalizations in young children worldwide, but data are limited on the contribution of specific viruses to severe illness in South America. We describe clinical and laboratory findings from prospective surveillance for acute respiratory infections at a tertiary hospital in São Paulo, Brazil. Methods We screened children < 2 years old with acute respiratory tract infections admitted to an urban tertiary hospital for respiratory viruses from March 2008 through February 2010, using polymerase chain reaction assays. Results Respiratory viruses were identified in 378 (53%) of the 715 samples analyzed. Respiratory syncytial virus was the most commonly identified virus (52%), followed by adenovirus (27%) and Human metapneumovirus (12%). More than one virus was identified in 19% of specimens. Almost half of the samples (46%) were from children with underlying health conditions. We demonstrated that compared to the previously healthy group, those with comorbidities had a worse outcome in terms of severity, with prolonged hospital stay and more need of intensive care. Conclusion Identification of this high-risk population along with strategies for fast diagnosis might each help to reduce morbidity and mortality in this group. |
| Databáze: | OpenAIRE |
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