Chemical diversity of dietary phytochemicals and their mode of chemoprevention
| Autor: | Rabindra Nayak, Brundaban Sahu, Sujit K. Bhutia, Srimanta Patra, Chhandashree Behera, Mrutyunjay Jena, Biswajita Pradhan, Suryamani Patro |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Drug media_common.quotation_subject Apoptosis Review Article Bioinformatics Chemoprevention 01 natural sciences Applied Microbiology and Biotechnology 03 medical and health sciences 010608 biotechnology Autophagy medicine Adverse effect Cancer 030304 developmental biology media_common 0303 health sciences business.industry Cell cycle medicine.disease Dietary phytochemical Chemical diversity Personalized medicine Dietary Phytochemicals business TP248.13-248.65 Biotechnology |
| Zdroj: | Biotechnology Reports, Vol 30, Iss, Pp e00633-(2021) Biotechnology Reports |
| ISSN: | 2215-017X |
| DOI: | 10.1016/j.btre.2021.e00633 |
| Popis: | Highlights • Chemically diverse dietary phytochemicals exhibit anticancer activity owing to their antioxidant potential. • Dietary phytochemicals act as blocking and suppressing agents for exposition of chemoprevention. • Potent apoptosis and autophagy modulation is chief contributor for exhibition of anticancer efficacy. Despite the advancement in prognosis, diagnosis and treatment, cancer has emerged as the second leading cause of disease-associated death across the globe. With the remarkable application of synthetic drugs in cancer therapy and the onset of therapy-associated adverse effects, dietary phytochemicals have been materialized as potent anti-cancer drugs owing to their antioxidant, apoptosis and autophagy modulating activities. With dynamic regulation of apoptosis and autophagy in association with cell cycle regulation, inhibition in cellular proliferation, invasion and migration, dietary phytochemicals have emerged as potent anti-cancer pharmacophores. Dietary phytochemicals or their synthetic analogous as individual drug candidates or in combination with FDA approved chemotherapeutic drugs have exhibited potent anti-cancer efficacy. With the advancement in cancer therapeutics, dietary phytochemicals hold high prevalence for their use as precision and personalized medicine to replace conventional chemotherapeutic drugs. Hence, keeping these perspectives in mind, this review focuses on the diversity of dietary phytochemicals and their molecular mechanism of action in several cancer subtypes and tumor entities. Understanding the possible molecular key players involved, the use of dietary phytochemicals will thrive a new horizon in cancer therapy. |
| Databáze: | OpenAIRE |
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