The Help of HPV Integration Testing to Avoid the Misdiagnosis of a Patient with Stage Ia1 Cervical Cancer: A Case Report and Literature Review
| Autor: | Jialu Li, Xiaoli Zhang, Pengpeng Wang, Weiping Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Cervical cancer medicine.medical_specialty medicine.diagnostic_test cervical cancer business.industry Obstetrics Chronic Cervicitis Case Report medicine.disease DNA methylation detection Squamous intraepithelial lesion medicine.anatomical_structure Pathology Result Biopsy precancerous lesion of cervical cancer Molecular Medicine Medicine Stage (cooking) business HPV DNA Survival rate Cervix |
| Zdroj: | Pharmacogenomics and Personalized Medicine |
| ISSN: | 1178-7066 |
| DOI: | 10.2147/pgpm.s310345 |
| Popis: | Screening and prevention in the early stage of cervical cancer could improve the 5-year survival rate of cervical cancer by up to 90%. The occurrence rate of human papillomavirus (HPV) integration has gradually increased with the development of cervical lesions. Here, we report the case of a 43-year-old woman diagnosed with chronic cervicitis based on cervical biopsy results. After medical consultation, surgery was recommended to the patient considering her 64 HPV integration sites and other biochemical and clinical test results. The pathology result of the conical biopsy obtained during operation confirmed that both her cervix and the glands had high-grade squamous intraepithelial lesion or cervical intraepithelial neoplasia III (HSIL/CIN III). The patient underwent uterectomy and bilateral salpingectomy and was discharged thereafter. The diagnosis of the patient was revised to stage Ia1 cervical cancer. The number of HPV integration sites is suggested to be an auxiliary indicator in the early screening of cervical cancer for predicting high-grade CIN and invasive cervical cancer. |
| Databáze: | OpenAIRE |
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