Cardiovascular calcifications after radiation therapy for Hodgkin lymphoma: computed tomography detection and clinical correlation
| Autor: | Michael Thaler, Rivka Zissin, Pia Raanani, Raphael Pfeffer, Sara Apter, Judith Rozenman, Marjorie Hertz, David Ezra, Joseph Shemesh, Orith Portnoy |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Coronary Disease Computed tomography Clinical correlation immune system diseases hemic and lymphatic diseases Mediastinal Diseases medicine Humans In patient Radiation Injuries Aorta Radiotherapy medicine.diagnostic_test business.industry Calcinosis General Medicine Middle Aged Coronary Vessels Heart Valves Hodgkin Disease Radiation therapy Hodgkin lymphoma Female Radiology Cardiomyopathies Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business |
| Zdroj: | Coronary Artery Disease. 17:145-151 |
| ISSN: | 0954-6928 |
| DOI: | 10.1097/00019501-200603000-00008 |
| Popis: | To study cardiovascular calcifications, detected by computed tomography, in patients following mediastinal radiation for Hodgkin lymphoma, and correlate them with clinical findings.Fifteen patients,or=55 years, with computed tomography detected cardiovascular calcifications after mediastinal radiotherapy for Hodgkin lymphoma were identified during a 10-year period. Calcifications were evaluated for site and extent and were correlated with clinical data including symptoms and signs of heart disease, angiographic and surgical findings.Accelerated calcifications were detected in the coronary arteries (n=11), in the aorta (n=11), and in the aortic valve and the mitral apparatus (n=8). Calcifications were more extensive when radiation was given at a young age. Clinical evidence of cardiovascular disease included coronary events in three patients, valvular dysfunction in two, pericarditis in two and complete atrioventricular block in one. Seven patients had no cardiac symptoms.Early cardiovascular calcifications can be radiation associated. Such calcifications may represent radiation-induced atherosclerosis and can be detected by computed tomography even in asymptomatic patients. The implication of our findings is that spiral computed tomography may serve as a non-invasive modality to detect accelerated cardiovascular calcifications in high-risk asymptomatic patients who survived Hodgkin lymphoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|