Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis
Autor: | Laura L. Koth, N. Arger, Prescott G. Woodruff, Melissa Ho |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Sarcoidosis Enzyme-Linked Immunosorbent Assay Disease Chemokine CXCL9 Gastroenterology Article Pulmonary function testing Pathogenesis Interferon-gamma 03 medical and health sciences 0302 clinical medicine Cost of Illness Predictive Value of Tests Internal medicine parasitic diseases Humans Medicine 030212 general & internal medicine Lung Whole blood business.industry Middle Aged medicine.disease Survival Analysis Chemokine CXCL11 Respiratory Function Tests Chemokine CXCL10 Cross-Sectional Studies 030228 respiratory system Cohort Etiology CXCL9 Female business Biomarkers |
Zdroj: | Respir Med |
ISSN: | 0954-6111 |
Popis: | BACKGROUND: Sarcoidosis is a systemic granulomatous disease of unknown etiology that affects the lungs in 90% of patients, but has a wide range of disease manifestations and outcomes including chronic and progressive courses. Noninvasive biomarkers are needed to assess these outcomes and guide decisions for long term monitoring and treatment. Interferon-gamma (IFN-γ)-inducible chemotactic cytokines (chemokines), CXCL9, CXCL10 and CXCL11, show promise in this regard because they have been implicated in the pathogenesis of and reflect the burden of granulomatous inflammation. CXCL11 has been reported to have unique functional properties in modulating adaptive immunity in model systems so our goal was to examine serum levels of CXCL11 in relation to clinical outcomes in a heterogeneous cohort of sarcoidosis subjects. METHODS: CXCL19, CXCL10, and CXCL11 serum levels were measured in sarcoidosis and healthy subjects using ELISA assay. We determined relationships between CXCL11 and standard clinical inflammatory markers, expression of IFN-γ-related genes in whole blood, organ involvement, dyspnea scores, and measures of pulmonary function. RESULTS: In a cross-sectional analysis of 104 sarcoidosis subjects, serum CXCL11 was significantly elevated compared to 49 healthy controls (p < 0.001). CXCL11 was positively correlated with CXCL9 and CXCL10 (p < 0.001), sedimentation rate (p < 0.01), and mean expression of three IFN-γ-related genes in whole blood (GBP1, STAT1, and STAT2) (p < 0.001). CXCL11 was inversely correlated with FVC %predicted (%pred) and FEV1 %pred and higher levels were associated with higher patient-reported dyspnea scores. We found positive correlations between CXCL11 and number of organs involved. Using survival analyses, we found that CXCL11 levels were predictive of future pulmonary function test (PFT) decline (log rank |
Databáze: | OpenAIRE |
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